ID   H0YBT5_HUMAN            Unreviewed;        88 AA.
AC   H0YBT5;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   12-SEP-2018, entry version 37.
DE   SubName: Full=Proenkephalin-A {ECO:0000313|Ensembl:ENSP00000430268};
DE   Flags: Fragment;
GN   Name=PENK {ECO:0000313|Ensembl:ENSP00000430268};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000430268, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000430268, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000430268}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC023464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YBT5; -.
DR   PeptideAtlas; H0YBT5; -.
DR   Ensembl; ENST00000517415; ENSP00000430268; ENSG00000181195.
DR   UCSC; uc064mzf.1; human.
DR   EuPathDB; HostDB:ENSG00000181195.10; -.
DR   HGNC; HGNC:8831; PENK.
DR   OpenTargets; ENSG00000181195; -.
DR   eggNOG; ENOG410IJUY; Eukaryota.
DR   eggNOG; ENOG4110ZYD; LUCA.
DR   GeneTree; ENSGT00530000063761; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000181195; Expressed in 187 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; H0YBT5; baseline and differential.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR   InterPro; IPR006024; Opioid_neupept.
DR   InterPro; IPR000703; Proenkphlin_A.
DR   PANTHER; PTHR11438; PTHR11438; 1.
DR   PANTHER; PTHR11438:SF3; PTHR11438:SF3; 1.
DR   PRINTS; PR01029; PENKAPRCRSR.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22     88       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546093.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000430268}.
SQ   SEQUENCE   88 AA;  9995 MW;  88ECEF08F0408C3E CRC64;
     FLTLCTWLLL LGPGLLATVR AECSQDCATC SYRLVRPADI NFLKHPRIDQ FIHSTNEYLM
     EEAPDGGKSQ CNASKWRHGV LMEKQQDL
//