ID   H0YBH7_HUMAN            Unreviewed;       347 AA.
AC   H0YBH7;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 40.
DE   SubName: Full=Store-operated calcium entry-associated regulatory factor {ECO:0000313|Ensembl:ENSP00000429538};
DE   Flags: Fragment;
GN   Name=SARAF {ECO:0000313|Ensembl:ENSP00000429538};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429538, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000429538, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000429538}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC044849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YBH7; -.
DR   jPOST; H0YBH7; -.
DR   MaxQB; H0YBH7; -.
DR   PeptideAtlas; H0YBH7; -.
DR   PRIDE; H0YBH7; -.
DR   Ensembl; ENST00000521265; ENSP00000429538; ENSG00000133872.
DR   UCSC; uc064lri.1; human.
DR   EuPathDB; HostDB:ENSG00000133872.13; -.
DR   HGNC; HGNC:28789; SARAF.
DR   OpenTargets; ENSG00000133872; -.
DR   eggNOG; ENOG410IV9Z; Eukaryota.
DR   eggNOG; ENOG4111IKY; LUCA.
DR   GeneTree; ENSGT00390000013419; -.
DR   OMA; MRCTNQG; -.
DR   PhylomeDB; H0YBH7; -.
DR   ChiTaRS; SARAF; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000133872; Expressed in 239 organ(s), highest expression level in frontal cortex.
DR   ExpressionAtlas; H0YBH7; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IEA:InterPro.
DR   GO; GO:2001256; P:regulation of store-operated calcium entry; IEA:InterPro.
DR   InterPro; IPR009567; SARAF.
DR   PANTHER; PTHR15929; PTHR15929; 1.
DR   Pfam; PF06682; SARAF; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:H0YBH7,
KW   ECO:0000213|PeptideAtlas:H0YBH7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31    347       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546416.
FT   TRANSMEM    173    193       Helical. {ECO:0000256|SAM:Phobius}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000429538}.
SQ   SEQUENCE   347 AA;  37879 MW;  E33A68A50E19991F CRC64;
     XAAACGPGAA GYCLLLGLHL FLLTAGPALG WNDPDRMLLR DVKALTLHYD RYTTSRRLDP
     IPQLKCVGGT AGCDSYTPKV IQCQNKGWDG YDVQWECKTD LDIAYKFGKT VVSCEGYESS
     EDQYVLRGSC GLEYNLDYTE LGLQKLKESG KQHGFASFSD YYYKWSSADS CNMSGLITIV
     VLLGIAFVVY KLFLSDGQYS PPPYSEYPPF SHRYQRFTNS AGPPPPGFKS EFTGPQNTGH
     GATSGFGSAF TGQQGYENSG PGFWTGLGTG GILGYLFGSN RAATPFSDSW YYPSYPPSYP
     GTWNRAYSPL HGGSGSYSDM VVPGDDKVES WSQTLDAEIL DFSSLSL
//