ID   H0YA68_HUMAN            Unreviewed;       953 AA.
AC   H0YA68;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   13-FEB-2019, entry version 47.
DE   SubName: Full=Epididymis-specific alpha-mannosidase {ECO:0000313|Ensembl:ENSP00000426273};
DE   Flags: Fragment;
GN   Name=MAN2B2 {ECO:0000313|Ensembl:ENSP00000426273};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426273, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426273, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000426273}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC093323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YA68; -.
DR   jPOST; H0YA68; -.
DR   MaxQB; H0YA68; -.
DR   PeptideAtlas; H0YA68; -.
DR   PRIDE; H0YA68; -.
DR   Ensembl; ENST00000505907; ENSP00000426273; ENSG00000013288.
DR   UCSC; uc062uyh.1; human.
DR   EuPathDB; HostDB:ENSG00000013288.8; -.
DR   HGNC; HGNC:29623; MAN2B2.
DR   OpenTargets; ENSG00000013288; -.
DR   eggNOG; KOG1959; Eukaryota.
DR   eggNOG; ENOG410XQMZ; LUCA.
DR   GeneTree; ENSGT00940000153720; -.
DR   ChiTaRS; MAN2B2; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000013288; Expressed in 229 organ(s), highest expression level in tendon.
DR   ExpressionAtlas; H0YA68; baseline and differential.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1270.50; -; 2.
DR   Gene3D; 2.60.40.1180; -; 1.
DR   Gene3D; 3.20.110.10; -; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF74650; SSF74650; 1.
DR   SUPFAM; SSF88688; SSF88688; 1.
DR   SUPFAM; SSF88713; SSF88713; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:H0YA68,
KW   ECO:0000213|MaxQB:H0YA68, ECO:0000213|PeptideAtlas:H0YA68};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    953       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546405.
FT   DOMAIN      355    438       Alpha-mann_mid.
FT                                {ECO:0000259|SMART:SM00872}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000426273}.
SQ   SEQUENCE   953 AA;  107627 MW;  E18D46442FBA527C CRC64;
     XQLCWLPLLA PLLLLRPPGV QSAGPIRAFV VPHSHMDVGW VYTVQESMRA YAANVYTSVV
     EELARGQQRR FIAVEQEFFR LWWDGVASDQ QKYQVRQLLE EGRLEFVIGG QVMHDEAVTH
     LDDQILQLTE GHGFLYETFG IRPQFSWHVD PFGASATTPT LFALAGFNAH LGSRIDYDLK
     AAMQEARGLQ FVWRGSPSLS ERQEIFTHIM DQYSYCTPSH IPFSNRSGFY WNGVAVFPKP
     PQDGVYPNMS EPVTPANINL YAEALVANVK QRAAWFRTPH VLWPWGCDKQ FFNASVQFAN
     MDPLLDHINS HAAELGVSVQ YATLGDYFRA LHALNVTWRV RDHHDFLPYS TEPFQAWTGF
     YTSRSSLKGL ARRASALLYA GESMFTRYLW PAPRGHLDPT WALQQLQQLR WAVSEVQHHD
     AITGTESPKV RDMYATHLAS GMLGMRKLMA SIVLDELQPQ APMAASSDAG PAGHFASVYN
     PLAWTVTTIV TLTVGFPGVR VTDEAGHPVP SQIQNSTETP SAYDLLILTT IPGLSYRHYN
     IRPTAGAQEG TQEPAATVAS TLQFGRRLRR RTSHAGRYLV PVANDCYIVL LDQDTNLMHS
     IWERQSNRTV RVTQEFLEYH VNGDVKQGPI SDNYLFTPGK AAVPAWEAVE MEIVAGQLVT
     EIRQYFYRNM TAQNYTYAIR SRLTHVPQGH DGELLCHRIE QEYQAGPLEL NREAVLRTST
     NLNSQQVIYS DNNGYQMQRR PYVSYVNNSI ARNYYPMVQS AFMEDGKSRL VLLSERAHGI
     SSQGNGQVEV MLHRRLWNNF DWDLGYNLTL NDTSVVHPVL WLLLGSWSLT TALRQRSALA
     LQHRPVVLFG DLAGTAPKLP GPQQQEAVTL PPNLHLQILS IPGWRYSSNH TEHSQNLRKG
     HRGEAQADLR RVLLRLYHLY EVGEDPVLSQ PVTVNLEVNF PTPIQTISQG SKP
//