ID   H0YA65_HUMAN            Unreviewed;       256 AA.
AC   H0YA65;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   05-DEC-2018, entry version 41.
DE   SubName: Full=Leucine-rich repeat LGI family member 2 {ECO:0000313|Ensembl:ENSP00000426254};
DE   Flags: Fragment;
GN   Name=LGI2 {ECO:0000313|Ensembl:ENSP00000426254};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426254, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426254, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000426254}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC113614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YA65; -.
DR   PRIDE; H0YA65; -.
DR   Ensembl; ENST00000512108; ENSP00000426254; ENSG00000153012.
DR   UCSC; uc062vqo.1; human.
DR   EuPathDB; HostDB:ENSG00000153012.11; -.
DR   HGNC; HGNC:18710; LGI2.
DR   OpenTargets; ENSG00000153012; -.
DR   eggNOG; ENOG410IIXR; Eukaryota.
DR   eggNOG; ENOG410XSZV; LUCA.
DR   GeneTree; ENSGT00940000157294; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000153012; Expressed in 149 organ(s), highest expression level in lower esophagus.
DR   ExpressionAtlas; H0YA65; baseline and differential.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 3.
DR   SMART; SM00082; LRRCT; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00597472};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    256       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546652.
FT   DOMAIN      158    207       LRRCT. {ECO:0000259|SMART:SM00082}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000426254}.
FT   NON_TER     256    256       {ECO:0000313|Ensembl:ENSP00000426254}.
SQ   SEQUENCE   256 AA;  28709 MW;  6E99DFE2FEE19FCD CRC64;
     XLGLLLLLLG AACLIPRSAQ VRRLARCPAT CSCTKESIIC VGSSWVPRIV PGDISSLSLV
     NGTFSEIKDR MFSHLPSLQL LLLNSNSFTI IRDDAFAGLF HLEYLFIEGN KIETISRNAF
     RGLRDLTHLS LANNHIKALP RDVFSDLDSL IELDLRGNKF ECDCKAKWLY LWLKMTNSTV
     SDVLCIGPPE YQEKKLNDVT SFDYECTTTD KQEEICEGKI QNLNARVVMN CSRPSSAFRK
     HTGNGRVAFF LPHGVR
//