ID   H0Y9P9_HUMAN            Unreviewed;       182 AA.
AC   H0Y9P9;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   13-FEB-2019, entry version 43.
DE   SubName: Full=Polyprenol reductase {ECO:0000313|Ensembl:ENSP00000424714};
DE   Flags: Fragment;
GN   Name=SRD5A3 {ECO:0000313|Ensembl:ENSP00000424714};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000424714, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000424714, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000424714}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC064824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC069200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0Y9P9; -.
DR   jPOST; H0Y9P9; -.
DR   MaxQB; H0Y9P9; -.
DR   PeptideAtlas; H0Y9P9; -.
DR   PRIDE; H0Y9P9; -.
DR   Ensembl; ENST00000505210; ENSP00000424714; ENSG00000128039.
DR   UCSC; uc062wrr.1; human.
DR   EuPathDB; HostDB:ENSG00000128039.10; -.
DR   HGNC; HGNC:25812; SRD5A3.
DR   OpenTargets; ENSG00000128039; -.
DR   eggNOG; KOG1640; Eukaryota.
DR   eggNOG; ENOG4111JQM; LUCA.
DR   GeneTree; ENSGT00500000044920; -.
DR   ChiTaRS; SRD5A3; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000128039; Expressed in 185 organ(s), highest expression level in palpebral conjunctiva.
DR   ExpressionAtlas; H0Y9P9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003865; F:3-oxo-5-alpha-steroid 4-dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR   InterPro; IPR039698; Dfg10/SRD5A3.
DR   PANTHER; PTHR14624; PTHR14624; 2.
DR   Pfam; PF02544; Steroid_dh; 1.
DR   PROSITE; PS50244; S5A_REDUCTASE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00125472, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:H0Y9P9,
KW   ECO:0000213|PeptideAtlas:H0Y9P9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00125472,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00125472,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    182       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546394.
FT   TRANSMEM     54     74       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    126    150       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      104    157       S5A_REDUCTASE.
FT                                {ECO:0000259|PROSITE:PS50244}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000424714}.
SQ   SEQUENCE   182 AA;  21036 MW;  0D8D35F73AC96B04 CRC64;
     FLLTLLLQLL PPGLLPGCAI FQDLIRYGKT KCGEPSRPAA CRAFDVPKRY FSHFYIISVL
     WNGFLLWCLT QSLFLGAPFP SWLHGLLRIL GAAQFQGVVI HCNHRIPFGD WFEYVSSPNY
     LAELMIYVSM AVTFGFHNLT WWLVVTNVFF NQALSAFLSH QFYKSKFVSY PKHRKAFLPF
     LF
//