ID   H0Y8R2_HUMAN            Unreviewed;       898 AA.
AC   H0Y8R2;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 2.
DT   05-DEC-2018, entry version 45.
DE   SubName: Full=Netrin receptor UNC5A {ECO:0000313|Ensembl:ENSP00000421795};
GN   Name=UNC5A {ECO:0000313|Ensembl:ENSP00000421795};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000421795, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000421795, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000421795}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC027318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006714991.1; XM_006714928.1.
DR   UniGene; Hs.33191; -.
DR   ProteinModelPortal; H0Y8R2; -.
DR   PeptideAtlas; H0Y8R2; -.
DR   PRIDE; H0Y8R2; -.
DR   Ensembl; ENST00000509580; ENSP00000421795; ENSG00000113763.
DR   GeneID; 90249; -.
DR   UCSC; uc063kag.1; human.
DR   CTD; 90249; -.
DR   EuPathDB; HostDB:ENSG00000113763.10; -.
DR   HGNC; HGNC:12567; UNC5A.
DR   OpenTargets; ENSG00000113763; -.
DR   GeneTree; ENSGT00940000153287; -.
DR   ChiTaRS; UNC5A; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000113763; Expressed in 88 organ(s), highest expression level in endothelial cell.
DR   ExpressionAtlas; H0Y8R2; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005042; F:netrin receptor activity; IEA:InterPro.
DR   Gene3D; 2.20.100.10; -; 2.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR037936; UNC5.
DR   InterPro; IPR033772; UPA.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR12582; PTHR12582; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF00090; TSP_1; 2.
DR   Pfam; PF17217; UPA; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00209; TSP1; 2.
DR   SMART; SM00218; ZU5; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   SUPFAM; SSF82895; SSF82895; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 2.
DR   PROSITE; PS51145; ZU5; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:H0Y8R2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    898       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015325986.
FT   TRANSMEM    359    383       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      155    234       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      497    640       ZU5. {ECO:0000259|PROSITE:PS51145}.
SQ   SEQUENCE   898 AA;  98864 MW;  13B74DDE8A8F0B1E CRC64;
     MAVRPGLWPA LLGIVLAAWL RGSGAQQSAT VANPVPGANP DLLPHFLVEP EDVYIVKNKP
     VLLVCKAVPA TQIFFKCNGE WVRQVDHVIE RSTDGSSGLP TMEVRINVSR QQVEKVFGLE
     EYWCQCVAWS SSGTTKSQKA YIRIAYLRKN FEQEPLAKEV SLEQGIVLPC RPPEGIPPAE
     VEWLRNEDLV DPSLDPNVYI TREHSLVVRQ ARLADTANYT CVAKNIVARR RSASAAVIVY
     VNGGWSTWTE WSVCSASCGR GWQKRSRSCT NPAPLNGGAF CEGQNVQKTA CATLCPVDGS
     WSPWSKWSAC GLDCTHWRSR ECSDPAPRNG GEECQGTDLD TRNCTSDLCV HTASGPEDVA
     LYVGLIAVAV CLVLLLLVLI LVYCRKKEGL DSDVADSSIL TSGFQPVSIK PSKADNPHLL
     TIQPDLSTTT TTYQGSLCPR QDGPSPKFQL TNGHLLSPLG GGRHTLHHSS PTSEAEEFVS
     RLSTQNYFRS LPRGTSNMTY GTFNFLGGRL MIPNTGISLL IPPDAIPRGK IYEIYLTLHK
     PEDVRLPLAG CQTLLSPIVS CGPPGVLLTR PVILAMDHCG EPSPDSWSLR LKKQSCEGSW
     EDVLHLGEEA PSHLYYCQLE ASACYVFTEQ LGRFALVGEA LSVAAAKRLK LLLFAPVACT
     SLEYNIRVYC LHDTHDALKE VVQLEKQLGG QLIQEPRVLH FKDSYHNLRL SIHDVPSSLW
     KSKLLVSYQE IPFYHIWNGT QRYLHCTFTL ERVSPSTSDL ACKLWVWQVE GDGQSFSINF
     NITKDTRFAE LLALESEAGV PALVGPSAFK IPFLIRQKII SSLDPPCRRG ADWRTLAQKL
     HLDSHLSFFA SKPSPTAMIL NLWEARHFPN GNLSQLAAAV AGLGQPDAGL FTVSEAEC
//