ID   H0Y8B3_HUMAN            Unreviewed;       518 AA.
AC   H0Y8B3;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 46.
DE   RecName: Full=Adenosylhomocysteinase {ECO:0000256|RuleBase:RU000548};
DE            EC=3.3.1.1 {ECO:0000256|RuleBase:RU000548};
DE   Flags: Fragment;
GN   Name=AHCYL2 {ECO:0000313|Ensembl:ENSP00000419346};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000419346, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000419346, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000419346}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + S-adenosyl-L-homocysteine = adenosine + L-
CC         homocysteine; Xref=Rhea:RHEA:21708, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:16335, ChEBI:CHEBI:57856, ChEBI:CHEBI:58199;
CC         EC=3.3.1.1; Evidence={ECO:0000256|RuleBase:RU000548};
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|RuleBase:RU000548};
CC       Note=Binds 1 NAD(+) per subunit. {ECO:0000256|RuleBase:RU000548};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-
CC       homocysteine from S-adenosyl-L-homocysteine: step 1/1.
CC       {ECO:0000256|RuleBase:RU000548}.
CC   -!- SIMILARITY: Belongs to the adenosylhomocysteinase family.
CC       {ECO:0000256|RuleBase:RU004166}.
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DR   EMBL; AC009244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC083866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0Y8B3; -.
DR   jPOST; H0Y8B3; -.
DR   MaxQB; H0Y8B3; -.
DR   PeptideAtlas; H0Y8B3; -.
DR   PRIDE; H0Y8B3; -.
DR   Ensembl; ENST00000466924; ENSP00000419346; ENSG00000158467.
DR   UCSC; uc064hxb.1; human.
DR   EuPathDB; HostDB:ENSG00000158467.16; -.
DR   HGNC; HGNC:22204; AHCYL2.
DR   OpenTargets; ENSG00000158467; -.
DR   eggNOG; KOG1370; Eukaryota.
DR   eggNOG; COG0499; LUCA.
DR   GeneTree; ENSGT00940000153650; -.
DR   UniPathway; UPA00314; UER00076.
DR   ChiTaRS; AHCYL2; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000158467; Expressed in 203 organ(s), highest expression level in colonic mucosa.
DR   ExpressionAtlas; H0Y8B3; baseline and differential.
DR   GO; GO:0004013; F:adenosylhomocysteinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00401; SAHH; 1.
DR   InterPro; IPR000043; Adenosylhomocysteinase-like.
DR   InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020082; S-Ado-L-homoCys_hydrolase_CS.
DR   PANTHER; PTHR23420; PTHR23420; 1.
DR   Pfam; PF05221; AdoHcyase; 1.
DR   Pfam; PF00670; AdoHcyase_NAD; 1.
DR   PIRSF; PIRSF001109; Ad_hcy_hydrolase; 1.
DR   SMART; SM00996; AdoHcyase; 1.
DR   SMART; SM00997; AdoHcyase_NAD; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00936; ahcY; 1.
DR   PROSITE; PS00738; ADOHCYASE_1; 1.
DR   PROSITE; PS00739; ADOHCYASE_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrolase {ECO:0000256|RuleBase:RU000548};
KW   NAD {ECO:0000256|RuleBase:RU000548};
KW   One-carbon metabolism {ECO:0000256|RuleBase:RU000548};
KW   Proteomics identification {ECO:0000213|EPD:H0Y8B3,
KW   ECO:0000213|MaxQB:H0Y8B3, ECO:0000213|PeptideAtlas:H0Y8B3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    518       Adenosylhomocysteinase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003545828.
FT   DOMAIN      277    438       AdoHcyase_NAD.
FT                                {ECO:0000259|SMART:SM00997}.
FT   COILED      108    128       {ECO:0000256|SAM:Coils}.
FT   BINDING     143    143       Substrate.
FT                                {ECO:0000256|PIRSR:PIRSR001109-1}.
FT   BINDING     217    217       Substrate.
FT                                {ECO:0000256|PIRSR:PIRSR001109-1}.
FT   BINDING     242    242       Substrate.
FT                                {ECO:0000256|PIRSR:PIRSR001109-1}.
FT   BINDING     272    272       Substrate.
FT                                {ECO:0000256|PIRSR:PIRSR001109-1}.
FT   BINDING     276    276       Substrate.
FT                                {ECO:0000256|PIRSR:PIRSR001109-1}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000419346}.
SQ   SEQUENCE   518 AA;  58116 MW;  52CA137959CF9FA5 CRC64;
     XRKWSRQFLL SFWCTVCSAH QGTIFLSLKI QFADQKQEFN KRPTKIGRRS LSRSISQSST
     DSYSSAASYT DSSDDETSPR DKQQKNSKGS SDFCVKNIKQ AEFGRREIEI AEQEMPALMA
     LRKRAQGEKP LAGAKIVGCT HITAQTAVLM ETLGALGAQC RWAACNIYST LNEVAAALAE
     SGFPVFAWKG ESEDDFWWCI DRCVNVEGWQ PNMILDDGGD LTHWIYKKYP NMFKKIKGIV
     EESVTGVHRL YQLSKAGKLC VPAMNVNDSV TKQKFDNLYC CRESILDGLK RTTDMMFGGK
     QVVVCGYGEV GKGCCAALKA MGSIVYVTEI DPICALQACM DGFRLVKLNE VIRQVDIVIT
     CTGNKNVVTR EHLDRMKNSC IVCNMGHSNT EIDVASLRTP ELTWERVRSQ VDHVIWPDGK
     RIVLLAEGRL LNLSCSTVPT FVLSITATTQ ALALIELYNA PEGRYKQDVY LLPKKMDEYV
     ASLHLPTFDA HLTELTDEQA KYLGLNKNGP FKPNYYRY
//