ID   H0Y7Y7_HUMAN            Unreviewed;       218 AA.
AC   H0Y7Y7;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 46.
DE   SubName: Full=HLA class II histocompatibility antigen, DQ beta 2 chain {ECO:0000313|Ensembl:ENSP00000415997};
DE   Flags: Fragment;
GN   Name=HLA-DQB2 {ECO:0000313|Ensembl:ENSP00000415997};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000415997, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000415997, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000415997}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the MHC class II family.
CC       {ECO:0000256|SAAS:SAAS00552561}.
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DR   EMBL; AL672104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0Y7Y7; -.
DR   jPOST; H0Y7Y7; -.
DR   PRIDE; H0Y7Y7; -.
DR   Ensembl; ENST00000427449; ENSP00000415997; ENSG00000232629.
DR   UCSC; uc063nrr.1; human.
DR   EuPathDB; HostDB:ENSG00000232629.8; -.
DR   HGNC; HGNC:4945; HLA-DQB2.
DR   OpenTargets; ENSG00000232629; -.
DR   eggNOG; ENOG410IWG3; Eukaryota.
DR   eggNOG; ENOG410YI0S; LUCA.
DR   GeneTree; ENSGT00940000154723; -.
DR   ChiTaRS; HLA-DQB2; human.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000232629; Expressed in 120 organ(s), highest expression level in skin of abdomen.
DR   ExpressionAtlas; H0Y7Y7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.10.320.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR000353; MHC_II_b_N.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00969; MHC_II_beta; 1.
DR   ProDom; PD000328; MHC_II_b_N; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00921; MHC_II_beta; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00437961};
KW   Immunity {ECO:0000256|SAAS:SAAS00437896};
KW   Membrane {ECO:0000256|SAAS:SAAS00437953};
KW   MHC II {ECO:0000256|SAAS:SAAS00437896};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:H0Y7Y7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00437953};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00437953}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    218       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003545822.
FT   DOMAIN      123    211       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000415997}.
SQ   SEQUENCE   218 AA;  25211 MW;  6CB551B77127115C CRC64;
     XLQIPGGFWA AAVTVMLVML STPVAEARDF PKDFLVQFKG MCYFTNGTER VRGVARYIYN
     REEYGRFDSD VGEFQAVTEL GRSIEDWNNY KDFLEQERAA VDKVCRHNYE AELRTTLQRQ
     VEPTVTISPS RTEALNHHNL LVCSVTDFYP AQIKVRWFRN DQEETAGVVS TSLIRNGDWT
     FQILVMLEIT PQRGDIYTCQ VEHPSLQSPI TVEWRLLH
//