ID   H0Y7V6_HUMAN            Unreviewed;       374 AA.
AC   H0Y7V6;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   05-DEC-2018, entry version 43.
DE   SubName: Full=Pulmonary surfactant-associated protein B {ECO:0000313|Ensembl:ENSP00000415347};
DE   Flags: Fragment;
GN   Name=SFTPB {ECO:0000313|Ensembl:ENSP00000415347};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000415347, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000415347, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000415347}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC012454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0Y7V6; -.
DR   PeptideAtlas; H0Y7V6; -.
DR   PRIDE; H0Y7V6; -.
DR   Ensembl; ENST00000428225; ENSP00000415347; ENSG00000168878.
DR   UCSC; uc061ljc.1; human.
DR   EuPathDB; HostDB:ENSG00000168878.16; -.
DR   HGNC; HGNC:10801; SFTPB.
DR   OpenTargets; ENSG00000168878; -.
DR   eggNOG; KOG1340; Eukaryota.
DR   eggNOG; ENOG410XSI5; LUCA.
DR   GeneTree; ENSGT00940000161711; -.
DR   ChiTaRS; SFTPB; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000168878; Expressed in 211 organ(s), highest expression level in visceral pleura.
DR   ExpressionAtlas; H0Y7V6; baseline and differential.
DR   GO; GO:0005764; C:lysosome; IEA:InterPro.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IEA:InterPro.
DR   InterPro; IPR003119; SAP_A.
DR   InterPro; IPR007856; SapB_1.
DR   InterPro; IPR008138; SapB_2.
DR   InterPro; IPR008373; Saposin.
DR   InterPro; IPR011001; Saposin-like.
DR   InterPro; IPR008139; SaposinB_dom.
DR   Pfam; PF02199; SapA; 1.
DR   Pfam; PF05184; SapB_1; 1.
DR   Pfam; PF03489; SapB_2; 2.
DR   PRINTS; PR01797; SAPOSIN.
DR   SMART; SM00162; SAPA; 1.
DR   SMART; SM00741; SapB; 3.
DR   SUPFAM; SSF47862; SSF47862; 3.
DR   PROSITE; PS51110; SAP_A; 1.
DR   PROSITE; PS50015; SAP_B; 3.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:H0Y7V6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    374       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546057.
FT   DOMAIN       22     62       Saposin A-type.
FT                                {ECO:0000259|PROSITE:PS51110}.
FT   DOMAIN       62    144       Saposin B-type.
FT                                {ECO:0000259|PROSITE:PS50015}.
FT   DOMAIN      201    278       Saposin B-type.
FT                                {ECO:0000259|PROSITE:PS50015}.
FT   DOMAIN      288    363       Saposin B-type.
FT                                {ECO:0000259|PROSITE:PS50015}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000415347}.
SQ   SEQUENCE   374 AA;  41468 MW;  C6CA5D259D490E87 CRC64;
     XHLLQWLLLL LPTLCGPGTA AWTTSSLACA QGPEFWCQSL EQALQCRALG HCLQEVWGHV
     GADDLCQECE DIVHILNKMA KEAIFQDTMR KFLEQECNVL PLKLLMPQCN QVLDDYFPLV
     IDYFQNQTDS NGICMHLGLC KSRQPEPEQE PGMSDPLPKP LRDPLPDPLL DKLVLPVLPG
     ALQARPGPHT QDLSEQQFPI PLPYCWLCRA LIKRIQAMIP KGALAVAVAQ VCRVVPLVAG
     GICQCLAERY SVILLDTLLG RMLPQLVCRL VLRCSMDDSA GPREWLPRDS ECHLCMSVTT
     QAGNSSEQAI PQAMLQACVG SWLDREKCKQ FVEQHTPQLL TLVPRGWDAH TTCQALGVCG
     TMSSPLQCIH SPDL
//