ID H0Y7L5_HUMAN Unreviewed; 269 AA. AC H0Y7L5; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 16-JAN-2019, entry version 47. DE SubName: Full=Apolipoprotein E {ECO:0000313|Ensembl:ENSP00000413653}; DE Flags: Fragment; GN Name=APOE {ECO:0000313|Ensembl:ENSP00000413653}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000413653, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000413653, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:22905912} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22905912; DOI=10.1021/pr300539b; RA Rosenow A., Noben J.P., Jocken J., Kallendrusch S., RA Fischer-Posovszky P., Mariman E.C., Renes J.; RT "Resveratrol-induced changes of the human adipocyte secretion RT profile."; RL J. Proteome Res. 11:4733-4743(2012). RN [4] {ECO:0000313|Ensembl:ENSP00000413653} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. RN [5] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00412673}. CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family. CC {ECO:0000256|SAAS:SAAS00598075}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC011481; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0Y7L5; -. DR jPOST; H0Y7L5; -. DR MaxQB; H0Y7L5; -. DR PeptideAtlas; H0Y7L5; -. DR PRIDE; H0Y7L5; -. DR Ensembl; ENST00000434152; ENSP00000413653; ENSG00000130203. DR UCSC; uc060zug.1; human. DR EuPathDB; HostDB:ENSG00000130203.9; -. DR HGNC; HGNC:613; APOE. DR OpenTargets; ENSG00000130203; -. DR eggNOG; ENOG410IVK0; Eukaryota. DR eggNOG; ENOG4111MYC; LUCA. DR GeneTree; ENSGT00730000111315; -. DR ChiTaRS; APOE; human. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000130203; Expressed in 224 organ(s), highest expression level in left adrenal gland. DR ExpressionAtlas; H0Y7L5; baseline and differential. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0008289; F:lipid binding; IEA:InterPro. DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW. DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro. DR InterPro; IPR000074; ApoA_E. DR Pfam; PF01442; Apolipoprotein; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Lipid transport {ECO:0000256|SAAS:SAAS00491985}; KW Proteomics identification {ECO:0000213|MaxQB:H0Y7L5, KW ECO:0000213|PeptideAtlas:H0Y7L5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Secreted {ECO:0000256|SAAS:SAAS00491987}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transport {ECO:0000256|SAAS:SAAS00491985}. FT SIGNAL 1 44 {ECO:0000256|SAM:SignalP}. FT CHAIN 45 269 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003545881. FT COILED 101 125 {ECO:0000256|SAM:Coils}. FT COILED 182 202 {ECO:0000256|SAM:Coils}. FT NON_TER 269 269 {ECO:0000313|Ensembl:ENSP00000413653}. SQ SEQUENCE 269 AA; 30638 MW; 811092B8D5F3E0BB CRC64; MSSGASRKSW DPGNPWPPDW PITGRKMKVL WAALLVTFLA GCQAKVEQAV ETEPEPELRQ QTEWQSGQRW ELALGRFWDY LRWVQTLSEQ VQEELLSSQV TQELRALMDE TMKELKAYKS ELEEQLTPVA EETRARLSKE LQAAQARLGA DMEDVCGRLV QYRGEVQAML GQSTEELRVR LASHLRKLRK RLLRDADDLQ KRLAVYQAGA REGAERGLSA IRERLGPLVE QGRVRAATVG SLAGQPLQER AQAWGERLRA RMEEMGSRT //