ID   H0Y7I8_HUMAN            Unreviewed;       164 AA.
AC   H0Y7I8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   05-DEC-2018, entry version 51.
DE   SubName: Full=Voltage-dependent N-type calcium channel subunit alpha-1B {ECO:0000313|Ensembl:ENSP00000413042};
DE   Flags: Fragment;
GN   Name=CACNA1B {ECO:0000313|Ensembl:ENSP00000413042};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000413042, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000413042, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000413042}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AL591424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL772363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0Y7I8; -.
DR   PeptideAtlas; H0Y7I8; -.
DR   PRIDE; H0Y7I8; -.
DR   Ensembl; ENST00000413253; ENSP00000413042; ENSG00000148408.
DR   UCSC; uc064xoc.1; human.
DR   EuPathDB; HostDB:ENSG00000148408.12; -.
DR   HGNC; HGNC:1389; CACNA1B.
DR   OpenTargets; ENSG00000148408; -.
DR   GeneTree; ENSGT00940000155275; -.
DR   ChiTaRS; CACNA1B; human.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000148408; Expressed in 90 organ(s), highest expression level in middle temporal gyrus.
DR   ExpressionAtlas; H0Y7I8; baseline and differential.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:H0Y7I8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    164       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008415115.
FT   TRANSMEM     50     73       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        2     83       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN       93    146       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000413042}.
FT   NON_TER     164    164       {ECO:0000313|Ensembl:ENSP00000413042}.
SQ   SEQUENCE   164 AA;  18950 MW;  D4A6C6E3F96D719A CRC64;
     XNFRTFLQAL MLLFRSATGE AWHEIMLSCL SNQACDEQAN ATECGSDFAY FYFVSFIFLC
     SFLMLNLFVA VIMDNFEYLT RDSSILGPHH LDEFIRVWAE YDPAACCRIH YKDMYSLLRC
     IAPPVGLGKN CPRRLAYKRL VRMNMPISNE DMTVHFTSTL MALI
//