ID   H0Y7G6_HUMAN            Unreviewed;       236 AA.
AC   H0Y7G6;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   05-DEC-2018, entry version 37.
DE   SubName: Full=Neuroligin-4, Y-linked {ECO:0000313|Ensembl:ENSP00000412638};
DE   Flags: Fragment;
GN   Name=NLGN4Y {ECO:0000313|Ensembl:ENSP00000412638};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000412638, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000412638, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12815422; DOI=10.1038/nature01722;
RA   Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S.,
RA   Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T.,
RA   Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G.,
RA   Fulton L., Fulton R., Graves T.A., Hou S.-F., Latrielle P.,
RA   Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W.,
RA   Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K.,
RA   Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H.,
RA   Wilson R.K., Rozen S., Page D.C.;
RT   "The male-specific region of the human Y chromosome is a mosaic of
RT   discrete sequence classes.";
RL   Nature 423:825-837(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000412638}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC010726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0Y7G6; -.
DR   ESTHER; human-NLGN4Y; Neuroligin.
DR   EPD; H0Y7G6; -.
DR   PeptideAtlas; H0Y7G6; -.
DR   PRIDE; H0Y7G6; -.
DR   Ensembl; ENST00000413217; ENSP00000412638; ENSG00000165246.
DR   UCSC; uc065csk.1; human.
DR   EuPathDB; HostDB:ENSG00000165246.12; -.
DR   HGNC; HGNC:15529; NLGN4Y.
DR   OpenTargets; ENSG00000165246; -.
DR   GeneTree; ENSGT00940000156607; -.
DR   ChiTaRS; NLGN4Y; human.
DR   Proteomes; UP000005640; Chromosome Y.
DR   Bgee; ENSG00000165246; Expressed in 130 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; H0Y7G6; baseline and differential.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0045202; C:synapse; IEA:InterPro.
DR   GO; GO:0042043; F:neurexin family protein binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0050808; P:synapse organization; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019819; Carboxylesterase_B_CS.
DR   InterPro; IPR030025; NLGN4.
DR   PANTHER; PTHR43903:SF5; PTHR43903:SF5; 1.
DR   Pfam; PF00135; COesterase; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    236       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546631.
FT   DOMAIN       25    209       COesterase. {ECO:0000259|Pfam:PF00135}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000412638}.
SQ   SEQUENCE   236 AA;  26583 MW;  7DED96FE7981FC4E CRC64;
     XNSNVLLWIT ALAIKFTLID SQAQYPVVNT NYGKIQGLRT PLPSEILGPV EQYLGVPYAS
     PPTGERRFQP PESPSSWTGI RNATQFSAVC PQHLDERFLL HDMLPIWFTT SLDTLMTYVQ
     DQNEDCLYLN IYVPMEDGTN IKRNADDITS NDHGEDKDIH EQNSKKPVMV YIHGGSYMEG
     TGNMIDGSIL ASYGNVIVIT INYRLGILGM QEARLCGSSK MFNYFKSPFT NLINFF
//