ID   H0Y6N7_HUMAN            Unreviewed;       556 AA.
AC   H0Y6N7;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 47.
DE   SubName: Full=Potassium voltage-gated channel subfamily KQT member 4 {ECO:0000313|Ensembl:ENSP00000406735};
DE   Flags: Fragment;
GN   Name=KCNQ4 {ECO:0000313|Ensembl:ENSP00000406735};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000406735, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000406735, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000406735}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
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DR   EMBL; AC119677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF495919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0Y6N7; -.
DR   jPOST; H0Y6N7; -.
DR   PRIDE; H0Y6N7; -.
DR   Ensembl; ENST00000443478; ENSP00000406735; ENSG00000117013.
DR   UCSC; uc057fgw.1; human.
DR   EuPathDB; HostDB:ENSG00000117013.14; -.
DR   HGNC; HGNC:6298; KCNQ4.
DR   OpenTargets; ENSG00000117013; -.
DR   GeneTree; ENSGT00940000159209; -.
DR   ChiTaRS; KCNQ4; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000117013; Expressed in 128 organ(s), highest expression level in pigmented layer of retina.
DR   ExpressionAtlas; H0Y6N7; baseline and differential.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR   InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR   InterPro; IPR015573; KCQN4.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 2.
DR   PANTHER; PTHR11537:SF4; PTHR11537:SF4; 2.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF03520; KCNQ_channel; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01459; KCNQCHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417246};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417246};
KW   Membrane {ECO:0000256|SAAS:SAAS00417245, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417246};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00417245,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00417245,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417246}.
FT   SIGNAL        1     15       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        16    556       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5012316639.
FT   TRANSMEM     28     49       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     70     95       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    135    154       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    195    220       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        3    220       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      325    507       KCNQ_channel. {ECO:0000259|Pfam:PF03520}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000406735}.
SQ   SEQUENCE   556 AA;  62754 MW;  8C4DF88BBE592D81 CRC64;
     XFLLVFSCLV LSVLSTIQEH QELANECLLI LEFVMIVVFG LEYIVRVWSA GCCCRYRGWQ
     GRFRFARKPF CVIDFIVFVA SVAVIAAGTQ GNIFATSALR SMRFLQILRM VRMDRRGGTW
     KLLGSVVYAH SKELITAWYI GFLVLIFASF LVYLAEKDAN SDFSSYADSL WWGTITLTTI
     GYGDKTPHTW LGRVLAAGFA LLGISFFALP AGILGSGFAL KVQEQHRQKH FEKRRMPAAN
     LIQAAWRLYS TDMSRAYLTA TWYYYDSILP SFSQMFNNKR SFFRIHASWR PSSRMGIKDR
     IRMGSSQRRT GPSKQHLAPP TMPTSPSSEQ VGEATSPTKV QKSWSFNDRT RFRASLRLKP
     RTSAEDAPSE EVAEEKSYQC ELTVDDIMPA VKTVIRSIRI LKFLVAKRKF KETLRPYDVK
     DVIEQYSAGH LDMLGRIKSL QTRVDQIVGR GPGDRKAREK GDKGPSDAEV VDEISMMGRV
     VKVEKQVQSI EHKLDLLLGF YSRCLRSGTS ASLGAVQVPL FDPDITSDYH SPVDHEDISV
     SAQTLSISRS VSTNMD
//