ID   H0Y4J5_HUMAN            Unreviewed;       227 AA.
AC   H0Y4J5;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   05-DEC-2018, entry version 46.
DE   SubName: Full=Protein disulfide-isomerase A2 {ECO:0000313|Ensembl:ENSP00000392277};
DE   Flags: Fragment;
GN   Name=PDIA2 {ECO:0000313|Ensembl:ENSP00000392277};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000392277, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000392277, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000392277}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; Z69667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0Y4J5; -.
DR   MaxQB; H0Y4J5; -.
DR   PeptideAtlas; H0Y4J5; -.
DR   PRIDE; H0Y4J5; -.
DR   Ensembl; ENST00000456379; ENSP00000392277; ENSG00000185615.
DR   UCSC; uc059oiy.1; human.
DR   EuPathDB; HostDB:ENSG00000185615.15; -.
DR   HGNC; HGNC:14180; PDIA2.
DR   OpenTargets; ENSG00000185615; -.
DR   GeneTree; ENSGT00940000161859; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000185615; Expressed in 113 organ(s), highest expression level in body of pancreas.
DR   ExpressionAtlas; H0Y4J5; baseline and differential.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 2.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:H0Y4J5,
KW   ECO:0000213|PeptideAtlas:H0Y4J5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    227       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546025.
FT   DOMAIN       24    149       Thioredoxin.
FT                                {ECO:0000259|PROSITE:PS51352}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000392277}.
FT   NON_TER     227    227       {ECO:0000313|Ensembl:ENSP00000392277}.
SQ   SEQUENCE   227 AA;  25142 MW;  11EF631FFD82B08C CRC64;
     XLLPVLLLLL LRASCPWGQE QGARSPSEEP PEEEIPKEDG ILVLSRHTLG LALREHPALL
     VEFYAPWCGH CQALAPEYSK AAAVLAAESM VVTLAKVDGP AQRELAEEFG VTEYPTLKFF
     RNGNRTHPEE YTGPRDAEGI AEWLRRRVGP SAMRLEDEAA AQALIGGRDL VVIGFFQDAL
     DMTFGLTDRP RLFQQFGLTK DTVVLFKKFD EGRADFPVDE ELGLDLG
//