ID   H0Y4I5_HUMAN            Unreviewed;       684 AA.
AC   H0Y4I5;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 45.
DE   SubName: Full=Chondroadherin-like protein {ECO:0000313|Ensembl:ENSP00000392046};
DE   Flags: Fragment;
GN   Name=CHADL {ECO:0000313|Ensembl:ENSP00000392046};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000392046, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000392046, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M.,
RA   Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K.,
RA   Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J.,
RA   Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G.,
RA   Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R.,
RA   Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E.,
RA   Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G.,
RA   Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S.,
RA   Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A.,
RA   Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M.,
RA   Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T.,
RA   Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J.,
RA   Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T.,
RA   Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T.,
RA   Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L.,
RA   Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M.,
RA   Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J.,
RA   Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S.,
RA   Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T.,
RA   Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I.,
RA   Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H.,
RA   Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L.,
RA   Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z.,
RA   Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P.,
RA   Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S.,
RA   Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J.,
RA   Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T.,
RA   Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J.,
RA   Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S.,
RA   Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E.,
RA   Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P.,
RA   Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E.,
RA   O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X.,
RA   Khan A.S., Lane L., Tilahun Y., Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [2] {ECO:0000313|Ensembl:ENSP00000392046}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AL035681; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0Y4I5; -.
DR   jPOST; H0Y4I5; -.
DR   PeptideAtlas; H0Y4I5; -.
DR   PRIDE; H0Y4I5; -.
DR   Ensembl; ENST00000417999; ENSP00000392046; ENSG00000100399.
DR   UCSC; uc062eqc.1; human.
DR   EuPathDB; HostDB:ENSG00000100399.15; -.
DR   HGNC; HGNC:25165; CHADL.
DR   OpenTargets; ENSG00000100399; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   eggNOG; COG4886; LUCA.
DR   GeneTree; ENSGT00940000154464; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   Bgee; ENSG00000100399; Expressed in 117 organ(s), highest expression level in C1 segment of cervical spinal cord.
DR   ExpressionAtlas; H0Y4I5; baseline and differential.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   Pfam; PF13855; LRR_8; 5.
DR   SMART; SM00369; LRR_TYP; 19.
DR   SMART; SM00013; LRRNT; 2.
DR   PROSITE; PS51450; LRR; 17.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Leucine-rich repeat {ECO:0000256|SAAS:SAAS00138699};
KW   Proteomics identification {ECO:0000213|MaxQB:H0Y4I5,
KW   ECO:0000213|PeptideAtlas:H0Y4I5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00490532};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29    684       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546607.
FT   DOMAIN       30     64       LRRNT. {ECO:0000259|SMART:SM00013}.
FT   DOMAIN      393    427       LRRNT. {ECO:0000259|SMART:SM00013}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000392046}.
SQ   SEQUENCE   684 AA;  73949 MW;  4D954C697C6D48D4 CRC64;
     XPRSSTHVPL VLPLLVLLLL APARQAAAQR CPQACICDNS RRHVACRYQN LTEVPDAIPE
     LTQRLDLQGN LLKVIPAAAF QGVPHLTHLD LRHCEVELVA EGAFRGLGRL LLLNLASNHL
     RELPQEALDG LGSLRRLELE GNALEELRPG TFGALGALAT LNLAHNALVY LPAMAFQGLL
     RVRWLRLSHN ALSVLAPEAL AGLPALRRLS LHHNELQALP GPVLSQARGL ARLELGHNPL
     TYAGEEDGLA LPGLRELLLD GGALQALGPR AFAHCPRLHT LDLRGNQLDT LPPLQGPGQL
     RRLRLQGNPL WCGCQARPLL EWLARARVRS DGACQGPRRL RGEALDALRP WDLRCPGDAA
     QEEEELEERA VAGPRAPPRG PPRGPGEERA VAPCPRACVC VPESRHSSCE GCGLQAVPRG
     FPSDTQLLDL RRNHFPSVPR AAFPGLGHLV SLHLQHCGIA ELEAGALAGL GRLIYLYLSD
     NQLAGLSAAA LEGAPRLGYL YLERNRFLQV PGAALRALPS LFSLHLQDNA VDRLAPGDLG
     RTRALRWVYL SGNRITEVSL GALGPARELE KLHLDRNQLR EVPTGALEGL PALLELQLSG
     NPLRALRDGA FQPVGRSLQH LFLNSSGLEQ ICPGAFSGLG PGLQSLHLQK NQLRALPALP
     SARRTPIKGR QCGADKVGKE KGRL
//