ID   H0Y3K2_HUMAN            Unreviewed;       950 AA.
AC   H0Y3K2;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 41.
DE   SubName: Full=E3 ubiquitin-protein ligase UBR3 {ECO:0000313|Ensembl:ENSP00000376409};
DE   Flags: Fragment;
GN   Name=UBR3 {ECO:0000313|Ensembl:ENSP00000376409};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000376409, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000376409, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000376409}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC009967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC092641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0Y3K2; -.
DR   jPOST; H0Y3K2; -.
DR   MaxQB; H0Y3K2; -.
DR   PeptideAtlas; H0Y3K2; -.
DR   PRIDE; H0Y3K2; -.
DR   Ensembl; ENST00000392632; ENSP00000376409; ENSG00000144357.
DR   UCSC; uc061pjq.1; human.
DR   EuPathDB; HostDB:ENSG00000144357.16; -.
DR   HGNC; HGNC:30467; UBR3.
DR   OpenTargets; ENSG00000144357; -.
DR   eggNOG; KOG1139; Eukaryota.
DR   eggNOG; ENOG410XRM3; LUCA.
DR   GeneTree; ENSGT00940000154767; -.
DR   ChiTaRS; UBR3; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000144357; Expressed in 209 organ(s), highest expression level in biceps brachii.
DR   ExpressionAtlas; H0Y3K2; baseline and differential.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0071596; P:ubiquitin-dependent protein catabolic process via the N-end rule pathway; IEA:InterPro.
DR   InterPro; IPR039164; UBR1-like.
DR   PANTHER; PTHR21497; PTHR21497; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:H0Y3K2,
KW   ECO:0000213|MaxQB:H0Y3K2, ECO:0000213|PeptideAtlas:H0Y3K2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    950       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003545844.
FT   COILED      227    247       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000376409}.
SQ   SEQUENCE   950 AA;  107613 MW;  840BF04C60ECB024 CRC64;
     XSEHVLCMVL YLIELGLENS AEEESDEEAS VGGPERCHDS WFPGSNLVSN MRHFINYVRV
     RVPETAPEVK RDSPASTSSD NLGSLQNSGT AQVFSLVAER RKKFQEIINR SSSEANQVVR
     PKTSSKWSAP GSAPQLTTAI LEIKESILSL LIKLHHKLSG KQNSYYPPWL DDIEILIQPE
     IPKYSHGDGI TAVERILLKA ASQSRMNKRI IEEICRKVTP PVPPKKVTAA EKKTLDKEER
     RQKARERQQK LLAEFASRQK SFMETAMDVD SPENDIPMEI TTAEPQVSEA VYDCVICGQS
     GPSSEDRPTG LVVLLQASSV LGQCRDNVEP KKLPISEEEQ IYPWDTCAAV HDVRLSLLQR
     YFKDSSCLLA VSIGWEGGVY VQTCGHTLHI DCHKSYMESL RNDQVLQGFS VDKGEFTCPL
     CRQFANSVLP CYPGSNVENN PWQRPSNKSI QDLIKEVEEL QGRPGAFPVS ISSETNLSKE
     MESVMKDIKN TTQKKYRDYS KTPGSPDNDF LFMYSVARTN LELELIHRGG NLCSGGASTA
     GKRSCLNQLF HVLALHMRLY SIDSEYNPWR KLTQLEEMNP QLGYEEQQPE VPILYHDVTS
     LLLIQILMMP QPLRKDHFTC IVKVLFTLLY TQALAALSVK CSEEDRSAWK HAGALKKSTC
     DAEKSYEVLL SFVISELFKG KLYHEEGTQE CAMVNPIAWS PESMEKCLQD FCLPFLRITS
     LLQHHLFGED LPSCQEEEEF SVLASCLGLL PTFYQTEHPF ISASCLDWPV PAFDIITQWC
     FEIKSFTERH AEQGKALLIQ ESKWKLPHLL QLPENYNTIF QYYHRKTCSV CTKVPKDPAV
     CLVCGTFVCL KGLCCKQQSY CECVLHSQNC GAGTGIFLLI NASVIIIIRG HRFCLWGSVY
     LDAHGEEDRD LRRGKPLYIC KERYKVLEQQ WISHTFDHIN KRWGPHYNGL
//