ID   H0Y3H6_HUMAN            Unreviewed;       526 AA.
AC   H0Y3H6;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 57.
DE   SubName: Full=Complement C2 {ECO:0000313|Ensembl:ENSP00000372664};
DE   Flags: Fragment;
GN   Name=C2 {ECO:0000313|Ensembl:ENSP00000372664};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000372664, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000372664, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000372664}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00559343}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR   EMBL; AL645922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL671762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0Y3H6; -.
DR   jPOST; H0Y3H6; -.
DR   MaxQB; H0Y3H6; -.
DR   PeptideAtlas; H0Y3H6; -.
DR   PRIDE; H0Y3H6; -.
DR   Ensembl; ENST00000383177; ENSP00000372664; ENSG00000166278.
DR   UCSC; uc063njk.1; human.
DR   EuPathDB; HostDB:ENSG00000166278.14; -.
DR   HGNC; HGNC:1248; C2.
DR   OpenTargets; ENSG00000166278; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00940000162934; -.
DR   ChiTaRS; C2; human.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000166278; Expressed in 96 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; H0Y3H6; baseline and differential.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006958; P:complement activation, classical pathway; IEA:InterPro.
DR   CDD; cd00033; CCP; 1.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR037568; Complement_C2.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR19325:SF387; PTHR19325:SF387; 2.
DR   Pfam; PF00084; Sushi; 1.
DR   Pfam; PF00089; Trypsin; 1.
DR   Pfam; PF00092; VWA; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00032; CCP; 1.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   SUPFAM; SSF57535; SSF57535; 1.
DR   PROSITE; PS50923; SUSHI; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00302,
KW   ECO:0000256|SAAS:SAAS00037407};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|RuleBase:RU363034};
KW   Proteomics identification {ECO:0000213|MaxQB:H0Y3H6,
KW   ECO:0000213|PeptideAtlas:H0Y3H6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Serine protease {ECO:0000256|RuleBase:RU363034};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    526       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546014.
FT   DOMAIN       14     71       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      100    226       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   DOMAIN      238    518       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
FT   DISULFID     42     69       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000372664}.
SQ   SEQUENCE   526 AA;  58900 MW;  B84A9CB8033A5330 CRC64;
     XMVLFCLLFL YPAGHCPNPG ISLGAVRTGF RFGHGDKVRY RCSSNLVLTG SSERECQGNG
     VWSGTEPICR QPYSYDFPED VAPALGTSFS HMLGATNPTQ KTKDHENGTG TNTYAALNSV
     YLMMNNQMRL LGMETMAWQE IRHAIILLTD GKSNMGGSPK TAVDHIREIL NINQKRNDYL
     DIYAIGVGKL DVDWRELNEL GSKKDGERHA FILQDTKALH QVFEHMLDVS KLTDTICGVG
     NMSANASDQE RTPWHVTIKP KSQETCRGAL ISDQWVLTAA HCFRDGNDHS LWRVNVGDPK
     SQWGKEFLIE KAVISPGFDV FAKKNQGILE FYGDDIALLK LAQKVKMSTH ARPICLPCTM
     EANLALRRPQ GSTCRDHENE LLNKQSVPAH FVALNGSKLN INLKMGVEWT SCAEVVSQEK
     TMFPNLTDVR EVVTDQFLCS GTQEDESPCK GESGGAVFLE RRFRFFQVGL VSWGLYNPCL
     GSADKNSRKR APRSKVPPPR DFHINLFRMQ PWLRQHLGDV LNFLPL
//