ID   H0Y2X7_HUMAN            Unreviewed;       230 AA.
AC   H0Y2X7;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 42.
DE   SubName: Full=Large neutral amino acids transporter small subunit 2 {ECO:0000313|Ensembl:ENSP00000343949};
DE   Flags: Fragment;
GN   Name=SLC7A8 {ECO:0000313|Ensembl:ENSP00000343949};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000343949, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000343949, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000343949}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AL117258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0Y2X7; -.
DR   jPOST; H0Y2X7; -.
DR   PeptideAtlas; H0Y2X7; -.
DR   Ensembl; ENST00000339733; ENSP00000343949; ENSG00000092068.
DR   UCSC; uc058zpd.1; human.
DR   EuPathDB; HostDB:ENSG00000092068.18; -.
DR   HGNC; HGNC:11066; SLC7A8.
DR   OpenTargets; ENSG00000092068; -.
DR   eggNOG; KOG1287; Eukaryota.
DR   eggNOG; COG0531; LUCA.
DR   GeneTree; ENSGT00940000158278; -.
DR   ChiTaRS; SLC7A8; human.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000092068; Expressed in 228 organ(s), highest expression level in cortex of kidney.
DR   ExpressionAtlas; H0Y2X7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   Pfam; PF13520; AA_permease_2; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:H0Y2X7,
KW   ECO:0000213|PeptideAtlas:H0Y2X7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    230       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546010.
FT   TRANSMEM     68     89       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    165    184       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    190    212       Helical. {ECO:0000256|SAM:Phobius}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000343949}.
SQ   SEQUENCE   230 AA;  26093 MW;  A3ECF0446C8DD617 CRC64;
     XCLQEHSQPS QLLCTLLLCW CVLGRERPFR KAQSTSSPLE GVPRFLKRLL LTWVNCSSVR
     WATRVQDIFT AGKLLALALI IIMGIVQICK GEYFWLEPKN AFENFQEPDI GLVALAFLQG
     SFAYGGWNFL NYVTEELVDP YKLFFAGARE GHLPSVLAMI HVKRCTPIPA LLFTCISTLL
     MLVTSDMYTL INYVGFINYL FYGVTVAGQI VLRWKKPDIP RPIKPLPYQG
//