ID   H0Y2P9_HUMAN            Unreviewed;       276 AA.
AC   H0Y2P9;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 39.
DE   SubName: Full=Phosphatidylinositol-glycan biosynthesis class X protein {ECO:0000313|Ensembl:ENSP00000296333};
GN   Name=PIGX {ECO:0000313|Ensembl:ENSP00000296333};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000296333, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000296333, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000296333}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC055725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0Y2P9; -.
DR   STRING; 9606.ENSP00000296333; -.
DR   jPOST; H0Y2P9; -.
DR   MaxQB; H0Y2P9; -.
DR   PaxDb; H0Y2P9; -.
DR   PeptideAtlas; H0Y2P9; -.
DR   PRIDE; H0Y2P9; -.
DR   Ensembl; ENST00000296333; ENSP00000296333; ENSG00000163964.
DR   UCSC; uc062scb.1; human.
DR   EuPathDB; HostDB:ENSG00000163964.13; -.
DR   HGNC; HGNC:26046; PIGX.
DR   OpenTargets; ENSG00000163964; -.
DR   eggNOG; ENOG410IGQT; Eukaryota.
DR   eggNOG; ENOG410Y4AX; LUCA.
DR   GeneTree; ENSGT00390000017679; -.
DR   OMA; SKDICQW; -.
DR   PhylomeDB; H0Y2P9; -.
DR   TreeFam; TF323845; -.
DR   ChiTaRS; PIGX; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000163964; Expressed in 193 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; H0Y2P9; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:InterPro.
DR   InterPro; IPR013233; PIG-X/PBN1.
DR   InterPro; IPR040039; PIGX.
DR   PANTHER; PTHR28650; PTHR28650; 1.
DR   Pfam; PF08320; PIG-X; 1.
DR   SMART; SM00780; PIG-X; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:H0Y2P9,
KW   ECO:0000213|PeptideAtlas:H0Y2P9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30    276       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546598.
FT   TRANSMEM    246    269       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   276 AA;  30956 MW;  13A31473ED5A3EE3 CRC64;
     LAARVAAVRA AAWLLLGAAT GLTRGPAAAF TAARSDAGIR AMCSEIILRQ EVLKDGFHRD
     LLIKVKFGES IEDLHTCRLL IKQDIPAGLY VDPYELASLR ERNITEAVMV SENFDIEAPN
     YLSKESEVLI YARRDSQCID CFQAFLPVHC RYHRPHSEDG EASIVVNNPD LLMFCDQAGS
     RRMIRFRFDS FDKTIEFPIL KCWAHSEVAA PCALENEDIC QWNKMKYKSV YKNVILQVPV
     GLTVHTSLVC SVTLLITILC STLILVAVFK YGHFSL
//