ID   G8JL96_HUMAN            Unreviewed;      1501 AA.
AC   G8JL96;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   13-FEB-2019, entry version 58.
DE   SubName: Full=Receptor-type tyrosine-protein phosphatase S {ECO:0000313|Ensembl:ENSP00000262963};
GN   Name=PTPRS {ECO:0000313|Ensembl:ENSP00000262963};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000262963, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000262963, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000262963}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein]
CC         + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|SAAS:SAAS01128831};
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DR   EMBL; AC005335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC022517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC118535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; G8JL96; -.
DR   jPOST; G8JL96; -.
DR   PRIDE; G8JL96; -.
DR   Ensembl; ENST00000262963; ENSP00000262963; ENSG00000105426.
DR   UCSC; uc060sap.1; human.
DR   EuPathDB; HostDB:ENSG00000105426.14; -.
DR   HGNC; HGNC:9681; PTPRS.
DR   OpenTargets; ENSG00000105426; -.
DR   eggNOG; KOG4228; Eukaryota.
DR   eggNOG; COG5599; LUCA.
DR   GeneTree; ENSGT00940000153617; -.
DR   ChiTaRS; PTPRS; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000105426; Expressed in 203 organ(s), highest expression level in forebrain.
DR   ExpressionAtlas; G8JL96; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   CDD; cd00063; FN3; 4.
DR   Gene3D; 2.60.40.10; -; 7.
DR   Gene3D; 3.90.190.10; -; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTPase_domain.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; TYR_PHOSPHATASE_dom.
DR   Pfam; PF00041; fn3; 3.
DR   Pfam; PF07679; I-set; 3.
DR   Pfam; PF00102; Y_phosphatase; 2.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00060; FN3; 4.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 3.
DR   SMART; SM00194; PTPc; 2.
DR   SMART; SM00404; PTPc_motif; 2.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   SUPFAM; SSF49265; SSF49265; 2.
DR   SUPFAM; SSF52799; SSF52799; 2.
DR   PROSITE; PS50853; FN3; 4.
DR   PROSITE; PS50835; IG_LIKE; 3.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01031415};
KW   Membrane {ECO:0000256|SAAS:SAAS00897767, ECO:0000256|SAM:Phobius};
KW   Protein phosphatase {ECO:0000256|SAAS:SAAS01031415};
KW   Proteomics identification {ECO:0000213|EPD:G8JL96,
KW   ECO:0000213|MaxQB:G8JL96, ECO:0000213|PeptideAtlas:G8JL96};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00923712};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00897767,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00897767,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30   1501       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003510791.
FT   TRANSMEM    852    875       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       33    123       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      135    224       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      232    314       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      321    411       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      416    510       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      514    603       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      605    689       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      946   1201       Tyrosine-protein phosphatase.
FT                                {ECO:0000259|PROSITE:PS50055}.
FT   DOMAIN     1121   1192       TYR_PHOSPHATASE_2.
FT                                {ECO:0000259|PROSITE:PS50056}.
FT   DOMAIN     1233   1492       Tyrosine-protein phosphatase.
FT                                {ECO:0000259|PROSITE:PS50055}.
FT   DOMAIN     1410   1483       TYR_PHOSPHATASE_2.
FT                                {ECO:0000259|PROSITE:PS50056}.
FT   COILED      750    770       {ECO:0000256|SAM:Coils}.
FT   ACT_SITE   1142   1142       Phosphocysteine intermediate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00160}.
FT   ACT_SITE   1433   1433       Phosphocysteine intermediate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00160}.
SQ   SEQUENCE   1501 AA;  168430 MW;  27595E3A9F8A17B6 CRC64;
     MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA SFVCQATGDP
     KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR DENVYECVAQ NSVGEITVHA
     KLTVLREDQL PSGFPNIDMG PQLKVVERTR TATMLCAASG NPDPEITWFK DFLPVDPSAS
     NGRIKQLRSG ALQIESSEET DQGKYECVAT NSAGVRYSSP ANLYVRVRRV APRFSILPMS
     HEIMPGGNVN ITCVAVGSPM PYVKWMQGAE DLTPEDDMPV GRNVLELTDV KDSANYTCVA
     MSSLGVIEAV AQITVKSLPK APGTPMVTEN TATSITITWD SGNPDPVSYY VIEYKSKSQD
     GPYQIKEDIT TTRYSIGGLS PNSEYEIWVS AVNSIGQGPP SESVVTRTGE QAPASAPRNV
     QARMLSATTM IVQWEEPVEP NGLIRGYRVY YTMEPEHPVG NWQKHNVDDS LLTTVGSLLE
     DETYTVRVLA FTSVGDGPLS DPIQVKTQQG VPGQPMNLRA EARSETSITL SWSPPRQESI
     IKYELLFREG DHGREVGRTF DPTTSYVVED LKPNTEYAFR LAARSPQGLG AFTPVVRQRT
     LQSISPKNFK VKMIMKTSVL LSWEFPDNYN SPTPYKIQYN GLTLDVDGRT TKKLITHLKP
     HTFYNFVLTN RGSSLGGLQQ TVTAWTAFNL LNGKPSVAPK PDADGFIMVY LPDGQSPVPV
     QSYFIVMVPL RKSRGGQFLT PLGSPEDMDL EELIQDISRL QRRSLRHSRQ LEVPRPYIAA
     RFSVLPPTFH PGDQKQYGGF DNRGLEPGHR YVLFVLAVLQ KSEPTFAASP FSDPFQLDNP
     DPQPIVDGEE GLIWVIGPVL AVVFIICIVI AILLYKKKPH SKRKDSEPRT KCLLNNADLA
     PHHPKDPVEM RRINFQTPGM LSHPPIPIAD MAEHTERLKA NDSLKLSQEY ESIDPGQQFT
     WEHSNLEVNK PKNRYANVIA YDHSRVILQP IEGIMGSDYI NANYVDGYRC QNAYIATQGP
     LPETFGDFWR MVWEQRSATI VMMTRLEEKS RIKCDQYWPN RGTETYGFIQ VTLLDTIELA
     TFCVRTFSLH KNGSSEKREV RQFQFTAWPD HGVPEYPTPF LAFLRRVKTC NPPDAGPIVV
     HCSAGVGRTG CFIVIDAMLE RIKPEKTVDV YGHVTLMRSQ RNYMVQTEDQ YSFIHEALLE
     AVGCGNTEVP ARSLYAYIQK LAQVEPGEHV TGMELEFKRL ANSKAHTSRF ISANLPCNKF
     KNRLVNIMPY ESTRVCLQPI RGVEGSDYIN ASFIDGYRQQ KAYIATQGPL AETTEDFWRM
     LWENNSTIVV MLTKLREMGR EKCHQYWPAE RSARYQYFVV DPMAEYNMPQ YILREFKVTD
     ARDGQSRTVR QFQFTDWPEQ GVPKSGEGFI DFIGQVHKTK EQFGQDGPIS VHCSAGVGRT
     GVFITLSIVL ERMRYEGVVD IFQTVKMLRT QRPAMVQTED EYQFCYQAAL EYLGSFDHYA
     T
//