ID   G5E9G7_HUMAN            Unreviewed;      1705 AA.
AC   G5E9G7;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   16-JAN-2019, entry version 73.
DE   SubName: Full=Neurexin 2, isoform CRA_a {ECO:0000313|EMBL:EAW74277.1};
DE   SubName: Full=Neurexin-2 {ECO:0000313|Ensembl:ENSP00000386416};
GN   Name=NRXN2 {ECO:0000313|EMBL:EAW74277.1,
GN   ECO:0000313|Ensembl:ENSP00000386416};
GN   ORFNames=hCG_1810991 {ECO:0000313|EMBL:EAW74277.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000386416, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|EMBL:EAW74277.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11181995; DOI=10.1126/science.1058040;
RA   Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA   Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
RA   Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
RA   Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
RA   Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
RA   Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
RA   Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
RA   Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
RA   Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
RA   Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
RA   Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA   Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA   Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
RA   Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
RA   Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
RA   Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
RA   Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
RA   Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
RA   Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
RA   Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
RA   Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
RA   Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
RA   Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
RA   Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
RA   Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
RA   Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
RA   Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
RA   McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
RA   Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA   Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA   Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
RA   Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
RA   Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
RA   Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
RA   Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
RA   Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
RA   Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
RA   Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
RA   Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
RA   Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
RA   Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
RA   Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
RA   Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
RA   McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
RA   Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA   Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA   Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT   "The sequence of the human genome.";
RL   Science 291:1304-1351(2001).
RN   [2] {ECO:0000313|EMBL:EAW74277.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000386416, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [4] {ECO:0000313|Ensembl:ENSP00000386416}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; AP001092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471076; EAW74277.1; -; Genomic_DNA.
DR   RefSeq; XP_005274457.1; XM_005274400.3.
DR   UniGene; Hs.372938; -.
DR   jPOST; G5E9G7; -.
DR   PRIDE; G5E9G7; -.
DR   Ensembl; ENST00000409571; ENSP00000386416; ENSG00000110076.
DR   GeneID; 9379; -.
DR   UCSC; uc058cyc.1; human.
DR   CTD; 9379; -.
DR   EuPathDB; HostDB:ENSG00000110076.18; -.
DR   HGNC; HGNC:8009; NRXN2.
DR   OpenTargets; ENSG00000110076; -.
DR   eggNOG; KOG3514; Eukaryota.
DR   eggNOG; ENOG410XNU6; LUCA.
DR   GeneTree; ENSGT00940000155978; -.
DR   OrthoDB; 35129at2759; -.
DR   ChiTaRS; NRXN2; human.
DR   GenomeRNAi; 9379; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000110076; Expressed in 160 organ(s), highest expression level in right hemisphere of cerebellum.
DR   ExpressionAtlas; G5E9G7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR037440; Neurexin.
DR   InterPro; IPR003585; Neurexin-like.
DR   InterPro; IPR027789; Syndecan/Neurexin_dom.
DR   PANTHER; PTHR44287; PTHR44287; 1.
DR   Pfam; PF02210; Laminin_G_2; 6.
DR   Pfam; PF01034; Syndecan; 1.
DR   SMART; SM00294; 4.1m; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00282; LamG; 6.
DR   SUPFAM; SSF49899; SSF49899; 6.
DR   PROSITE; PS50026; EGF_3; 3.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00814887};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAAS:SAAS00094946, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:G5E9G7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00094946,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00094946,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29   1705       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014092034.
FT   TRANSMEM   1631   1651       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       28    206       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      202    242       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      289    479       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      486    679       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      683    720       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      725    897       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      911   1086       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN     1089   1126       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     1130   1338       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
SQ   SEQUENCE   1705 AA;  184114 MW;  3BD48907229A5A12 CRC64;
     MASGSRWRPT PPPLLLLLLL ALAARADGLE FGGGPGQWAR YARWAGAASS GELSFSLRTN
     ATRALLLYLD DGGDCDFLEL LLVDGRLRLR FTLSCAEPAT LQLDTPVADD RWHMVLLTRD
     ARRTALAVDG EARAAEVRSK RREMQVASDL FVGGIPPDVR LSALTLSTVK YEPPFRGLLA
     NLKLGERPPA LLGSQGLRGA TADPLCAPAR NPCANGGLCT VLAPGEVGCD CSHTGFGGKF
     CSEEEHPMEG PAHLTLNSEV GSLLFSEGGA GRGGAGDVHQ PTKGKEEFVA TFKGNEFFCY
     DLSHNPIQSS TDEITLAFRT LQRNGLMLHT GKSADYVNLS LKSGAVWLVI NLGSGAFEAL
     VEPVNGKFND NAWHDVRVTR NLRQHAGIGH AMVTISVDGI LTTTGYTQED YTMLGSDDFF
     YIGGSPNTAD LPGSPVSNNF MGCLKDVVYK NNDFKLELSR LAKEGDPKMK LQGDLSFRCE
     DVAALDPVTF ESPEAFVALP RWSAKRTGSI SLDFRTTEPN GLLLFSQGRR AGGGAGSHSS
     AQRADYFAME LLDGHLYLLL DMGSGGIKLR ASSRKVNDGE WCHVDFQRDG RKGSISVNSR
     STPFLATGDS EILDLESELY LGGLPEGGRV DLPLPPEVWT AALRAGYVGC VRDLFIDGRS
     RDLRGLAEAQ GAVGVAPFCS RETLKQCASA PCRNGGVCRE GWNRFICDCI GTGFLGRVCE
     REATVLSYDG SMYMKIMLPN AMHTEAEDVS LRFMSQRAYG LMMATTSRES ADTLRLELDG
     GQMKLTVNLD CLRVGCAPSK GPETLFAGHK LNDNEWHTVR VVRRGKSLQL SVDNVTVEGQ
     MAGAHMRLEF HNIETGIMTE RRFISVVPSN FIGHLSGLVF NGQPYMDQCK DGDITYCELN
     ARFGLRAIVA DPVTFKSRSS YLALATLQAY ASMHLFFQFK TTAPDGLLLF NSGNGNDFIV
     IELVKGYIHY VFDLGNGPSL MKGNSDKPVN DNQWHNVVVS RDPGNVHTLK IDSRTVTQHS
     NGARNLDLKG ELYIGGLSKN MFSNLPKLVA SRDGFQGCLA SVDLNGRLPD LIADALHRIG
     QVERGCDGPS TTCTEESCAN QGVCLQQWDG FTCDCTMTSY GGPVCNDPGT TYIFGKGGAL
     ITYTWPPNDR PSTRMDRLAV GFSTHQRSAV LVRVDSASGL GDYLQLHIDQ GTVGVIFNVG
     TDDITIDEPN AIVSDGKYHV VRFTRSGGNA TLQVDSWPVN ERYPAGNFDN ERLAIARQRI
     PYRLGRVVDE WLLDKGRQLT IFNSQAAIKI GGRDQGRPFQ GQVSGLYYNG LKVLALAAES
     DPNVRTEGHL RLVGEGPSVL LSAETTATTL LADMATTIME TTTTMATTTT RRGRSPTLRD
     STTQNTDDLL VASAECPSDD EDLEECEPST GGELILPIIT EDSLDPPPVA TRSPFVPPPP
     TFYPFLTGVG ATQDTLPPPA ARRPPSGGPC QAERDDSDCE EPIEASGFAS GEVFDSSLPP
     TDDEDFYTTF PLVTDRTTLL SPRKPAPRPN LRTDGATGAP GVLFAPSAPA PNLPAGKMNH
     RDPLQPLLEN PPLGPGAPTS FEPRRPPPLR PGVTSAPGFP HLPTANPTGP GERGPPGAVE
     VIRESSSTTG MVVGIVAAAA LCILILLYAM YKYRNRDEGS YQVDQSRNYI SNSAQSNGAV
     VKEKAPAAPK TPSKAKKNKD KEYYV
//