ID   G5E9F8_HUMAN            Unreviewed;       661 AA.
AC   G5E9F8;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   13-FEB-2019, entry version 71.
DE   SubName: Full=Vitamin K-dependent protein S {ECO:0000313|Ensembl:ENSP00000385794};
GN   Name=PROS1 {ECO:0000313|Ensembl:ENSP00000385794};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000385794, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000385794, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000385794}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; AC117474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC144562; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Hs.64016; -.
DR   jPOST; G5E9F8; -.
DR   MaxQB; G5E9F8; -.
DR   Ensembl; ENST00000407433; ENSP00000385794; ENSG00000184500.
DR   UCSC; uc003dqz.5; human.
DR   EuPathDB; HostDB:ENSG00000184500.14; -.
DR   HGNC; HGNC:9456; PROS1.
DR   OpenTargets; ENSG00000184500; -.
DR   eggNOG; ENOG410IGF6; Eukaryota.
DR   eggNOG; ENOG410ZTGU; LUCA.
DR   GeneTree; ENSGT00940000154035; -.
DR   ChiTaRS; PROS1; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000184500; Expressed in 227 organ(s), highest expression level in choroid plexus epithelium.
DR   ExpressionAtlas; G5E9F8; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0030195; P:negative regulation of blood coagulation; IEA:InterPro.
DR   Gene3D; 4.10.740.10; -; 1.
DR   InterPro; IPR017857; Coagulation_fac-like_Gla_dom.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR035972; GLA-like_dom_SF.
DR   InterPro; IPR000294; GLA_domain.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR033189; PROS1.
DR   PANTHER; PTHR24040:SF0; PTHR24040:SF0; 1.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF07645; EGF_CA; 2.
DR   Pfam; PF00594; Gla; 1.
DR   Pfam; PF00054; Laminin_G_1; 1.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   PRINTS; PR00001; GLABLOOD.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00179; EGF_CA; 4.
DR   SMART; SM00069; GLA; 1.
DR   SMART; SM00282; LamG; 2.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF57630; SSF57630; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 3.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 3.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS00011; GLA_1; 1.
DR   PROSITE; PS50998; GLA_2; 1.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00122,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00032677};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00966518};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    661       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5017334301.
FT   DOMAIN       41     87       Gla. {ECO:0000259|PROSITE:PS50998}.
FT   DOMAIN      117    155       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      186    227       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      228    268       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      284    460       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      469    651       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DISULFID    126    143       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    145    154       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    624    651       {ECO:0000256|PROSITE-ProRule:PRU00122}.
SQ   SEQUENCE   661 AA;  73474 MW;  710D68C0E197CA10 CRC64;
     MRVLGGRCGA LLACLLLVLP VSEANFLSKQ QASQVLVRKR RANSLLEETK QGNLERECIE
     ELCNKEEARE VFENDPETDY FYPKYLVCLR SFQTGLFTAA RQSTNAYPDL RSCVNAIPDQ
     CSPLPCNEDG YMSCKDGKAS FTCTCKPGWQ GEKCEFDINE CKDPSNINGG CSQICDNTPG
     SYHCSYVDEC SLKPSICGTA VCKNIPGDFE CECPEGYRYN LKSKSCEDID ECSENMCAQL
     CVNYPGGYTC YCDGKKGFKL AQDQKSCEVV SVCLPLNLDT KYELLYLAEQ FAGVVLYLKF
     RLPEISRFSA EFDFRTYDSE GVILYAESID HSAWLLIALR GGKIEVQLKN EHTSKITTGG
     DVINNGLWNM VSVEELEHSI SIKIAKEAVM DINKPGPLFK PENGLLETKV YFAGFPRKVE
     SELIKPINPR LDGCIRSWNL MKQGASGIKE IIQEKQNKHC LVTVEKGSYY PGSGIAQFHI
     DYNNVSSAEG WHVNVTLNIR PSTGTGVMLA LVSGNNTVPF AVSLVDSTSE KSQDILLSVE
     NTVIYRIQAL SLCSDQQSHL EFRVNRNNLE LSTPLKIETI SHEDLQRQLA VLDKAMKAKV
     ATYLGGLPDV PFSATPVNAF YNGCMEVNIN GVQLDLDEAI SKHNDIRAHS CPSVWKKTKN
     S
//