ID   G3XA84_HUMAN            Unreviewed;       169 AA.
AC   G3XA84;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   16-JAN-2019, entry version 53.
DE   SubName: Full=Placenta growth factor {ECO:0000313|Ensembl:ENSP00000238607};
GN   Name=PGF {ECO:0000313|Ensembl:ENSP00000238607};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000238607, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000238607, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000238607}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC       {ECO:0000256|RuleBase:RU003818, ECO:0000256|SAAS:SAAS00725102}.
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DR   EMBL; AC006530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001280572.1; NM_001293643.1.
DR   UniGene; Hs.252820; -.
DR   ProteinModelPortal; G3XA84; -.
DR   PRIDE; G3XA84; -.
DR   Ensembl; ENST00000238607; ENSP00000238607; ENSG00000119630.
DR   GeneID; 5228; -.
DR   UCSC; uc059dlk.1; human.
DR   CTD; 5228; -.
DR   EuPathDB; HostDB:ENSG00000119630.13; -.
DR   HGNC; HGNC:8893; PGF.
DR   OpenTargets; ENSG00000119630; -.
DR   eggNOG; ENOG410IY55; Eukaryota.
DR   eggNOG; ENOG410YNR0; LUCA.
DR   GeneTree; ENSGT00940000160164; -.
DR   OrthoDB; 1364454at2759; -.
DR   GenomeRNAi; 5228; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000119630; Expressed in 240 organ(s), highest expression level in inferior vagus X ganglion.
DR   ExpressionAtlas; G3XA84; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   CDD; cd00135; PDGF; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR023581; PD_growth_factor_CS.
DR   InterPro; IPR000072; PDGF/VEGF_dom.
DR   Pfam; PF00341; PDGF; 1.
DR   SMART; SM00141; PDGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00249; PDGF_1; 1.
DR   PROSITE; PS50278; PDGF_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00725120};
KW   Growth factor {ECO:0000256|RuleBase:RU003818,
KW   ECO:0000256|SAAS:SAAS00725099};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:G3XA84};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30    169       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003459768.
FT   DOMAIN       38    134       PDGF_2. {ECO:0000259|PROSITE:PS50278}.
SQ   SEQUENCE   169 AA;  19210 MW;  3A4E39334A9FE0B4 CRC64;
     MPVMRLFPCF LQLLAGLALP AVPPQWALSA GNGSSEVEVV PFQEVWGRSY CRALERLVDV
     VSEYPSEVEH MFSPSCVSLL RCTGCCGDEN LHCVPVETAN VTMQLLKIRS GDRPSYVELT
     FSQHVRCECR PLREKMKPER RRPKGRGKRR REKQRPTDCH LCGDAVPRR
//