ID   G3V5X3_HUMAN            Unreviewed;       202 AA.
AC   G3V5X3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   13-FEB-2019, entry version 45.
DE   SubName: Full=Cochlin {ECO:0000313|Ensembl:ENSP00000452569};
DE   Flags: Fragment;
GN   Name=COCH {ECO:0000313|Ensembl:ENSP00000452569};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000452569, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000452569, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000452569}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; AL049830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; G3V5X3; -.
DR   SMR; G3V5X3; -.
DR   PeptideAtlas; G3V5X3; -.
DR   PRIDE; G3V5X3; -.
DR   Ensembl; ENST00000555881; ENSP00000452569; ENSG00000100473.
DR   UCSC; uc059amv.1; human.
DR   EuPathDB; HostDB:ENSG00000100473.15; -.
DR   HGNC; HGNC:2180; COCH.
DR   OpenTargets; ENSG00000100473; -.
DR   eggNOG; ENOG410IR8D; Eukaryota.
DR   eggNOG; ENOG410XRIU; LUCA.
DR   GeneTree; ENSGT00940000159386; -.
DR   ChiTaRS; COCH; human.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000100473; Expressed in 220 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; G3V5X3; baseline and differential.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:InterPro.
DR   GO; GO:0045089; P:positive regulation of innate immune response; IEA:InterPro.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR030743; Cochlin.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR44729; PTHR44729; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:G3V5X3,
KW   ECO:0000213|MaxQB:G3V5X3, ECO:0000213|PeptideAtlas:G3V5X3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    202       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003457383.
FT   DOMAIN       47    202       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   NON_TER     202    202       {ECO:0000313|Ensembl:ENSP00000452569}.
SQ   SEQUENCE   202 AA;  21668 MW;  0484174C41B4ECC3 CRC64;
     MSAAWIPALG LGVCLLLLPG PAGSEGAGKR LKKTPEKKTG NKDCKADIAF LIDGSFNIGQ
     RRFNLQKNFV GKVALMLGIG TEGPHVGLVQ ASEHPKIEFY LKNFTSAKDV LFAIKEVGFR
     GGNSNTGKAL KHTAQKFFTV DAGVRKGIPK VVVVFIDGWP SDDIEEAGIV AREFGVNVFI
     VSVAKPIPEE LGMVQDVTFV DK
//