ID   G3V5V4_HUMAN            Unreviewed;       193 AA.
AC   G3V5V4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   13-FEB-2019, entry version 50.
DE   SubName: Full=Cochlin {ECO:0000313|Ensembl:ENSP00000452541};
DE   Flags: Fragment;
GN   Name=COCH {ECO:0000313|Ensembl:ENSP00000452541};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000452541, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000452541, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000452541}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; AL049830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; G3V5V4; -.
DR   SMR; G3V5V4; -.
DR   PeptideAtlas; G3V5V4; -.
DR   PRIDE; G3V5V4; -.
DR   Ensembl; ENST00000556908; ENSP00000452541; ENSG00000100473.
DR   UCSC; uc059amu.1; human.
DR   EuPathDB; HostDB:ENSG00000100473.15; -.
DR   HGNC; HGNC:2180; COCH.
DR   OpenTargets; ENSG00000100473; -.
DR   GeneTree; ENSGT00940000159386; -.
DR   ChiTaRS; COCH; human.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000100473; Expressed in 220 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; G3V5V4; baseline and differential.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:InterPro.
DR   GO; GO:0045089; P:positive regulation of innate immune response; IEA:InterPro.
DR   Gene3D; 2.170.130.20; -; 1.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR030743; Cochlin.
DR   InterPro; IPR004043; LCCL.
DR   InterPro; IPR036609; LCCL_sf.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR44729; PTHR44729; 1.
DR   Pfam; PF03815; LCCL; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00603; LCCL; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   SUPFAM; SSF69848; SSF69848; 1.
DR   PROSITE; PS50820; LCCL; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:G3V5V4,
KW   ECO:0000213|PeptideAtlas:G3V5V4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    193       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003457166.
FT   DOMAIN       12    105       LCCL. {ECO:0000259|PROSITE:PS50820}.
FT   DOMAIN      149    193       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   NON_TER     193    193       {ECO:0000313|Ensembl:ENSP00000452541}.
SQ   SEQUENCE   193 AA;  20371 MW;  51C57E95DE320CF1 CRC64;
     MSAAWIPALG LAPIAITCFT RGLDIRKEKA DVLCPGGCPL EEFSVYGNIV YASVSSICGA
     AVHRGVISNS GGPVRVYSLP GRENYSSVDA NGIQSQMLSR WSASFTVTKG KSSTQEATGQ
     AVSTAHPPTG KRLKKTPEKK TGNKDCKADI AFLIDGSFNI GQRRFNLQKN FVGKVALMLG
     IGTEGPHVGL VQA
//