ID   G3V5S4_HUMAN            Unreviewed;       304 AA.
AC   G3V5S4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   05-DEC-2018, entry version 49.
DE   SubName: Full=Paired box protein Pax-2 {ECO:0000313|Ensembl:ENSP00000452489};
DE   Flags: Fragment;
GN   Name=PAX2 {ECO:0000313|Ensembl:ENSP00000452489};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000452489, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000452489, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000452489}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00117811}.
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DR   EMBL; AL138762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL589862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; G3V5S4; -.
DR   PRIDE; G3V5S4; -.
DR   Ensembl; ENST00000554172; ENSP00000452489; ENSG00000075891.
DR   UCSC; uc057vks.1; human.
DR   EuPathDB; HostDB:ENSG00000075891.21; -.
DR   HGNC; HGNC:8616; PAX2.
DR   OpenTargets; ENSG00000075891; -.
DR   GeneTree; ENSGT00940000157412; -.
DR   ChiTaRS; PAX2; human.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000075891; Expressed in 64 organ(s), highest expression level in cortex of kidney.
DR   ExpressionAtlas; G3V5S4; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR   GO; GO:0005730; C:nucleolus; IDA:HPA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00131; PAX; 1.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001523; Paired_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00292; PAX; 1.
DR   PRINTS; PR00027; PAIREDBOX.
DR   SMART; SM00351; PAX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00034; PAIRED_1; 1.
DR   PROSITE; PS51057; PAIRED_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Developmental protein {ECO:0000256|SAAS:SAAS00117810};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00117818};
KW   Nucleus {ECO:0000256|SAAS:SAAS00117821};
KW   Paired box {ECO:0000256|SAAS:SAAS00117809};
KW   Proteomics identification {ECO:0000213|MaxQB:G3V5S4,
KW   ECO:0000213|PeptideAtlas:G3V5S4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transcription {ECO:0000256|SAAS:SAAS00117816};
KW   Transcription regulation {ECO:0000256|SAAS:SAAS00117816}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    304       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003457346.
FT   DOMAIN       20    146       Paired. {ECO:0000259|PROSITE:PS51057}.
FT   NON_TER     304    304       {ECO:0000313|Ensembl:ENSP00000452489}.
SQ   SEQUENCE   304 AA;  32383 MW;  84049A83C1E733CA CRC64;
     MAGPCCVWGV VFFSCLSPAG HGGVNQLGGV FVNGRPLPDV VRQRIVELAH QGVRPCDISR
     QLRVSHGCVS KILGRYYETG SIKPGVIGGS KPKVATPKVV DKIAEYKRQN PTMFAWEIRD
     RLLAEGICDN DTVPSVSSIN RIIRTKVQQP FHPTPDGAGT GVTAPGHTIV PSTASPPVSS
     ASNDPVGSYS INGILGIPRS NDVSEGSVPN GDSQSGVDSL RKHLRADTFT QQQLEALDRV
     FERPSYPDVF QASEHIKSEQ GNEYSLPALT PGLDEVKSSL SASTNPELGS NVSGTQTYPV
     VTGR
//