ID   G3V5P6_HUMAN            Unreviewed;       929 AA.
AC   G3V5P6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   16-JAN-2019, entry version 57.
DE   SubName: Full=Papilin {ECO:0000313|Ensembl:ENSP00000452455};
GN   Name=PAPLN {ECO:0000313|Ensembl:ENSP00000452455};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000452455, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000452455, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000452455}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC004846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; G3V5P6; -.
DR   jPOST; G3V5P6; -.
DR   PeptideAtlas; G3V5P6; -.
DR   PRIDE; G3V5P6; -.
DR   Ensembl; ENST00000555123; ENSP00000452455; ENSG00000100767.
DR   UCSC; uc059dbv.1; human.
DR   EuPathDB; HostDB:ENSG00000100767.15; -.
DR   HGNC; HGNC:19262; PAPLN.
DR   OpenTargets; ENSG00000100767; -.
DR   eggNOG; KOG3510; Eukaryota.
DR   eggNOG; KOG4597; Eukaryota.
DR   eggNOG; ENOG410XQNP; LUCA.
DR   GeneTree; ENSGT00940000156891; -.
DR   ChiTaRS; PAPLN; human.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000100767; Expressed in 176 organ(s), highest expression level in tendon.
DR   ExpressionAtlas; G3V5P6; baseline and differential.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd00109; KU; 1.
DR   Gene3D; 2.20.100.10; -; 5.
DR   Gene3D; 4.10.410.10; -; 1.
DR   InterPro; IPR010294; ADAM_spacer1.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR002223; Kunitz_BPTI.
DR   InterPro; IPR036880; Kunitz_BPTI_sf.
DR   InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF05986; ADAM_spacer1; 1.
DR   Pfam; PF00014; Kunitz_BPTI; 1.
DR   Pfam; PF00090; TSP_1; 5.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   PRINTS; PR00759; BASICPTASE.
DR   SMART; SM00131; KU; 1.
DR   SMART; SM00209; TSP1; 5.
DR   SUPFAM; SSF57362; SSF57362; 1.
DR   SUPFAM; SSF82895; SSF82895; 5.
DR   PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR   PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 5.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:G3V5P6,
KW   ECO:0000213|PeptideAtlas:G3V5P6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    929       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003456781.
FT   DOMAIN      727    777       BPTI/Kunitz inhibitor.
FT                                {ECO:0000259|PROSITE:PS50279}.
FT   DOMAIN      873    929       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   929 AA;  99821 MW;  5DEDB201A6102862 CRC64;
     MRLLLLVPLL LAPAPGSSAP KVRRQSDTWG PWSQWSPCSR TCGGGVSFRE RPCYSQRRDG
     GSSCVGPARS HRSCRTESCP DGARDFRAEQ CAEFDGAEFQ GRRYRWLPYY SAPNKCELNC
     IPKGENFYYK HREAVVDGTP CEPGKRDVCV DGSCRVVGCD HELDSSKQED KCLRCGGDGT
     TCYPVAGTFD ANDLSRAVKN VRGEYYLNGH WTIEAARALP AASTILHYER GAEGDLAPER
     LHARGPTSEP LVIELISQEP NPGVHYEYHL PLRRPSPGFS WSHGSWSDCS AECGGGHQSR
     LVFCTIDHEA YPDHMCQRQP RPADRRSCNL HPCPETKRWK AGPWAPCSAS CGGGSQSRSV
     YCISSDGAGI QEAVEEAECA GLPGKPPAIQ ACNLQRCAAW SPEPWGECSV SCGVGVRKRS
     VTCRGERGSL LHTAACSLED RPPLTEPCVH EDCPLLSDQA WHVGTWGLCS KSCSSGTRRR
     QVICAIGPPS HCGSLQHSKP VDVEPCNTQP CHLPQEVPSM QDVHTPASNP WMPLGPQESP
     ASDSRGQWWA AQEHPSARGD HRGERGDPRG DQGTHLSALG PAPSLQQPPY QQPLRSGSGP
     HDCRHSPHGC CPDGHTASLG PQWQGCPGAP CQQSRYGCCP DRVSVAEGPH HAGCTKSYGG
     DSTGGMPRSR AVASTVHNTH QPQAQQNEPS ECRGSQFGCC YDNVATAAGP LGEGCVGQPS
     HAYPVRCLLP SAHGSCADWA ARWYFVASVG QCNRFWYGGC HGNANNFASE QECMSSCQGS
     LHGPRRPQPG ASGRSTHTDG GGSSPAGEQE PSQHRTGAAV QRKPWPSGGL WRQDQQPGPG
     EAPHTQAFGE WPWGQELGSR APGLGGDAGS PAPPFHSSSY RISLAGVEPS LVQAALGQLV
     RLSCSDDTAP ESQAAWQKDG QPISSDRFT
//