ID   G3V5E8_HUMAN            Unreviewed;       211 AA.
AC   G3V5E8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   16-JAN-2019, entry version 41.
DE   SubName: Full=Galactocerebrosidase {ECO:0000313|Ensembl:ENSP00000452314};
GN   Name=GALC {ECO:0000313|Ensembl:ENSP00000452314};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000452314, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000452314, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000452314}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; AL136501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL157955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; G3V5E8; -.
DR   SMR; G3V5E8; -.
DR   jPOST; G3V5E8; -.
DR   MaxQB; G3V5E8; -.
DR   PeptideAtlas; G3V5E8; -.
DR   PRIDE; G3V5E8; -.
DR   Ensembl; ENST00000557316; ENSP00000452314; ENSG00000054983.
DR   UCSC; uc059eai.1; human.
DR   EuPathDB; HostDB:ENSG00000054983.16; -.
DR   HGNC; HGNC:4115; GALC.
DR   OpenTargets; ENSG00000054983; -.
DR   eggNOG; ENOG410IITE; Eukaryota.
DR   eggNOG; ENOG410XTIS; LUCA.
DR   GeneTree; ENSGT00390000003303; -.
DR   ChiTaRS; GALC; human.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000054983; Expressed in 238 organ(s), highest expression level in adrenal tissue.
DR   ExpressionAtlas; G3V5E8; baseline and differential.
DR   GO; GO:0004336; F:galactosylceramidase activity; IEA:InterPro.
DR   GO; GO:0006683; P:galactosylceramide catabolic process; IEA:InterPro.
DR   InterPro; IPR001286; Glyco_hydro_59.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR15172; PTHR15172; 1.
DR   Pfam; PF02057; Glyco_hydro_59; 1.
DR   PRINTS; PR00850; GLHYDRLASE59.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:G3V5E8,
KW   ECO:0000213|PeptideAtlas:G3V5E8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     42       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        43    211       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003457335.
SQ   SEQUENCE   211 AA;  23551 MW;  A7E3166C3584E623 CRC64;
     MAEWLLSASW QRRAKAMTAA AGSAGRAAVP LLLCALLAPG GAYVLDDSDG LGREFDGIGA
     VSGGGATSRL LVNYPEPYRS QILDYLFKPN FGASLHILKV EIGGDGQTTD GTEPSHMHYA
     LDENYFRGYE WWLMKEAKKR NPNITLIGLP WSFPGWLGKG FDWPYVNLQL TAYYVVTWIV
     GAKRYHDLDI DYIGIWNERS YNANYIKVFG E
//