ID G3V511_HUMAN Unreviewed; 1769 AA. AC G3V511; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 13-FEB-2019, entry version 59. DE SubName: Full=Latent-transforming growth factor beta-binding protein 2 {ECO:0000313|Ensembl:ENSP00000452110}; GN Name=LTBP2 {ECO:0000313|Ensembl:ENSP00000452110}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000452110, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000452110, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12508121; DOI=10.1038/nature01348; RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., RA Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., RA Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., RA Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., RA Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., RA Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., RA Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., RA Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., RA Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., RA Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., RA Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., RA Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., RA Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., RA Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., RA Quetier F., Waterston R., Hood L., Weissenbach J.; RT "The DNA sequence and analysis of human chromosome 14."; RL Nature 421:601-607(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000452110} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC005479; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC013451; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3V511; -. DR SwissPalm; G3V511; -. DR jPOST; G3V511; -. DR PeptideAtlas; G3V511; -. DR PRIDE; G3V511; -. DR Ensembl; ENST00000553939; ENSP00000452110; ENSG00000119681. DR UCSC; uc059diu.1; human. DR EuPathDB; HostDB:ENSG00000119681.11; -. DR HGNC; HGNC:6715; LTBP2. DR OpenTargets; ENSG00000119681; -. DR eggNOG; ENOG410IR7H; Eukaryota. DR eggNOG; ENOG410XSTY; LUCA. DR GeneTree; ENSGT00940000160884; -. DR ChiTaRS; LTBP2; human. DR Proteomes; UP000005640; Chromosome 14. DR Bgee; ENSG00000119681; Expressed in 219 organ(s), highest expression level in tendon of biceps brachii. DR ExpressionAtlas; G3V511; baseline and differential. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR Gene3D; 3.90.290.10; -; 4. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR017878; TB_dom. DR InterPro; IPR036773; TB_dom_sf. DR Pfam; PF07645; EGF_CA; 16. DR Pfam; PF00683; TB; 4. DR SMART; SM00181; EGF; 18. DR SMART; SM00179; EGF_CA; 16. DR SUPFAM; SSF57184; SSF57184; 5. DR SUPFAM; SSF57581; SSF57581; 4. DR PROSITE; PS00010; ASX_HYDROXYL; 11. DR PROSITE; PS00022; EGF_1; 2. DR PROSITE; PS01186; EGF_2; 8. DR PROSITE; PS50026; EGF_3; 13. DR PROSITE; PS01187; EGF_CA; 5. DR PROSITE; PS51364; TB; 4. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00032677}; KW Proteomics identification {ECO:0000213|MaxQB:G3V511, KW ECO:0000213|PeptideAtlas:G3V511}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00594563}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 35 {ECO:0000256|SAM:SignalP}. FT CHAIN 36 1769 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003457147. FT DOMAIN 187 219 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 396 428 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 552 595 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 622 662 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 672 724 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 844 886 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 887 923 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 930 969 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1010 1050 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1135 1175 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1176 1217 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1218 1253 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1303 1344 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1411 1463 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 1485 1527 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1528 1563 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1584 1636 TB. {ECO:0000259|PROSITE:PS51364}. FT DISULFID 191 201 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 209 218 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 400 410 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 418 427 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1532 1542 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 1769 AA; 189241 MW; 7B1BFFDA59D2A65A CRC64; MRPRTKARSP GRALRNPWRG FLPLTLALFV GAGHAQRDPV GRYEPAGGDA NRLRRPGGSY PAAAAAKVYS LFREQDAPVA GLQPVERAQP GWGSPRRPTE AEARRPSRAQ QSRRVQPPAQ TRRSTPLGQQ QPAPRTRAAP ALPRLGTPQR SGAAPPTPPR GRLTGRNVCG GQCCPGWTTA NSTNHCIKPV CEPPCQNRGS CSRPQLCVCR SGFRGARCEE VIPDEEFDPQ NSRLAPRRWA ERSPNLRRSS AAGEGTLARA QPPAPQSPPA PQSPPAGTLS GLSQTHPSQQ HVGLSRTVRL HPTATASSQL SSNALPPGPG LEQRDGTQQA VPLEHPSSPW GLNLTEKIKK IKIVFTPTIC KQTCARGHCA NSCERGDTTT LYSQGGHGHD PKSGFRIYFC QIPCLNGGRC IGRDECWCPA NSTGKFCHLP IPQPDREPPG RGSRPRALLE APLKQSTFTL PLSNQLASVN PSLVKVHIHH PPEASVQIHQ VAQVRGGVEE ALVENSVETR PPPWLPASPG HSLWDSNNIP ARSGEPPRPL PPAAPRPRGL LGRCYLNTVN GQCANPLLEL TTQEDCCGSV GAFWGVTLCA PCPPRPASPV IENGQLECPQ GYKRLNLTHC QDINECLTLG LCKDAECVNT RGSYLCTCRP GLMLDPSRSR CVSDKAISML QGLCYRSLGP GTCTLPLAQR ITKQICCCSR VGKAWGSECE KCPLPGTEAF REICPAGHGY TYASSDIRLS MRKAEEEELA RPPREQGQRS SGALPGPAER QPLRVVTDTW LEAGTIPDKG DSQAGQVTTS VTHAPAWVTG NATTPPMPEQ GIAEIQEEQV TPSTDVLVTL STPGIDRCAA GATNVCGPGT CVNLPDGYRC VCSPGYQLHP SQAYCTDDNE CLRDPCKGKG RCINRVGSYS CFCYPGYTLA TSGATQECQD INECEQPGVC SGGQCTNTEG SYHCECDQGY IMVRKGHCQD INECRHPGTC PDGRCVNSPG SYTCLACEEG YRGQSGSCVD VNECLTPGVC AHGKCTNLEG SFRCSCEQGY EVTSDEKGCQ DVDECASRAS CPTGLCLNTE GSFACSACEN GYWVNEDGTA CEDLDECAFP GVCPSGVCTN TAGSFSCKDC DGGYRPSPLG DSCEDVDECE DPQSSCLGGE CKNTVGSYQC LCPQGFQLAN GTVCEDVNEC MGEEHCAPHG ECLNSHGSFF CLCAPGFVSA EGGTSCQDVD ECATTDPCVG GHCVNTEGSF NCLCETGFQP SPESGECVDI DECEDYGDPV CGTWKCENSP GSYRCVLGCQ PGFHMAPNGD CIDIDECAND TMCGSHGFCD NTDGSFRCLC DQGFEISPSG WDCVDVNECE LMLAVCGAAL CENVEGSFLC LCASDLEEYD AQEGHCRPRG AGGQSMSEAP TGDHAPAPTR MDCYSGQKGH APCSSVLGRN TTQAECCCTQ GASWGDACDL CPSEDSAEFS EICPSGKGYI PVEGAWTFGQ TMYTDADECV IFGPGLCPNG RCLNTVPGYV CLCNPGFHYD ASHKKCEDHD ECQDLACENG ECVNTEGSFH CFCSPPLTLD LSQQRCMNST SSTEDLPDHD IHMDICWKKV TNDVCSEPLR GHRTTYTECC CQDGEAWSQQ CALCPPRSSE VYAQLCNVAR IEAEREAGVH FRPGYEYGPG PDDLHYSIYG PDGAPFYNYL GPEDTVPEPA FPNTAGHSAD RTPILESPLQ PSELQPHYVA SHPGLCCCKT GEEVGTKAVS LPSPPPASHI ASRSPQPASK GFRRRSAAS //