ID G3V4U0_HUMAN Unreviewed; 453 AA. AC G3V4U0; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 16-JAN-2019, entry version 64. DE SubName: Full=Fibulin-5 {ECO:0000313|Ensembl:ENSP00000451982}; GN Name=FBLN5 {ECO:0000313|Ensembl:ENSP00000451982}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000451982, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000451982, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12508121; DOI=10.1038/nature01348; RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., RA Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., RA Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., RA Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., RA Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., RA Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., RA Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., RA Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., RA Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., RA Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., RA Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., RA Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., RA Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., RA Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., RA Quetier F., Waterston R., Hood L., Weissenbach J.; RT "The DNA sequence and analysis of human chromosome 14."; RL Nature 421:601-607(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000451982} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL049872; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL590328; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF455988; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3V4U0; -. DR jPOST; G3V4U0; -. DR PRIDE; G3V4U0; -. DR Ensembl; ENST00000556154; ENSP00000451982; ENSG00000140092. DR UCSC; uc010aud.4; human. DR EuPathDB; HostDB:ENSG00000140092.14; -. DR HGNC; HGNC:3602; FBLN5. DR OpenTargets; ENSG00000140092; -. DR eggNOG; ENOG410IR76; Eukaryota. DR eggNOG; ENOG41104WD; LUCA. DR GeneTree; ENSGT00940000158774; -. DR Proteomes; UP000005640; Chromosome 14. DR Bgee; ENSG00000140092; Expressed in 199 organ(s), highest expression level in thoracic aorta. DR ExpressionAtlas; G3V4U0; baseline and differential. DR GO; GO:0005615; C:extracellular space; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0048251; P:elastic fiber assembly; IEA:InterPro. DR InterPro; IPR026823; cEGF. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR037288; Fibulin-5. DR InterPro; IPR037287; Fibulin_3/4/5. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR PANTHER; PTHR44074; PTHR44074; 1. DR PANTHER; PTHR44074:SF4; PTHR44074:SF4; 1. DR Pfam; PF12662; cEGF; 3. DR Pfam; PF07645; EGF_CA; 2. DR SMART; SM00181; EGF; 5. DR SMART; SM00179; EGF_CA; 6. DR SUPFAM; SSF57184; SSF57184; 2. DR PROSITE; PS00010; ASX_HYDROXYL; 4. DR PROSITE; PS01186; EGF_2; 4. DR PROSITE; PS50026; EGF_3; 5. DR PROSITE; PS01187; EGF_CA; 2. PE 1: Evidence at protein level; KW Calcium {ECO:0000256|SAAS:SAAS00909960}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00032677}; KW Proteomics identification {ECO:0000213|MaxQB:G3V4U0, KW ECO:0000213|PeptideAtlas:G3V4U0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00594563}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 453 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003456767. FT DOMAIN 47 87 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 132 172 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 173 211 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 212 251 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 252 292 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DISULFID 216 226 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 453 AA; 50881 MW; FD59A6714B251836 CRC64; MRSGNCRQRY MILTVTILAL CLPSPGNAQA QCTNGFDLDR QSGQCLDIDE CRTIPEACRG DMMCVNQNGG YLCIPRTNPV YRGPYSNPYS TPYSGPYPAA APPLSAPNYP TISRPLICRF GYQMDESNQC VDVDECATDS HQCNPTQICI NTEGGYTCSC TDGYWLLEGQ CLDIDECRYG YCQQLCANVP GSYSCTCNPG FTLNEDGRSC QDVNECATEN PCVQTCVNTY GSFICRCDPG YELEEDGVHC SDMDECSFSE FLCQHECVNQ PGTYFCSCPP GYILLDDNRS CQDINECEHR NHTCNLQQTC YNLQGGFKCI DPIRCEEPYL RISDNRCMCP AENPGCRDQP FTILYRDMDV VSGRSVPADI FQMQATTRYP GAYYIFQIKS GNEGREFYMR QTGPISATLV MTRPIKGPRE IQLDLEMITV NTVINFRGSS VIRLRIYVSQ YPF //