ID   G3V4M2_HUMAN            Unreviewed;       112 AA.
AC   G3V4M2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   16-JAN-2019, entry version 38.
DE   SubName: Full=Galactocerebrosidase {ECO:0000313|Ensembl:ENSP00000451884};
GN   Name=GALC {ECO:0000313|Ensembl:ENSP00000451884};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000451884, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000451884, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000451884}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; AL136501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL157955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; G3V4M2; -.
DR   jPOST; G3V4M2; -.
DR   MaxQB; G3V4M2; -.
DR   PeptideAtlas; G3V4M2; -.
DR   PRIDE; G3V4M2; -.
DR   Ensembl; ENST00000554372; ENSP00000451884; ENSG00000054983.
DR   UCSC; uc059eap.1; human.
DR   EuPathDB; HostDB:ENSG00000054983.16; -.
DR   HGNC; HGNC:4115; GALC.
DR   OpenTargets; ENSG00000054983; -.
DR   eggNOG; ENOG410IITE; Eukaryota.
DR   eggNOG; ENOG410XTIS; LUCA.
DR   GeneTree; ENSGT00390000003303; -.
DR   ChiTaRS; GALC; human.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000054983; Expressed in 238 organ(s), highest expression level in adrenal tissue.
DR   ExpressionAtlas; G3V4M2; baseline and differential.
DR   GO; GO:0004336; F:galactosylceramidase activity; IEA:InterPro.
DR   GO; GO:0006683; P:galactosylceramide catabolic process; IEA:InterPro.
DR   InterPro; IPR001286; Glyco_hydro_59.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR15172; PTHR15172; 1.
DR   Pfam; PF02057; Glyco_hydro_59; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:G3V4M2,
KW   ECO:0000213|PeptideAtlas:G3V4M2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     42       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        43    112       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003457361.
SQ   SEQUENCE   112 AA;  11695 MW;  8E982C1769F27229 CRC64;
     MAEWLLSASW QRRAKAMTAA AGSAGRAAVP LLLCALLAPG GAYVLDDSDG LGREFDGIGA
     VSGGGATSRL LVNYPEPYRS QILDYLFKPN FGASLHILKV EIGGDGQTTD IL
//