ID   G3V408_HUMAN            Unreviewed;        86 AA.
AC   G3V408;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   05-DEC-2018, entry version 48.
DE   SubName: Full=Gamma-aminobutyric acid receptor subunit alpha-5 {ECO:0000313|Ensembl:ENSP00000451527};
DE   Flags: Fragment;
GN   Name=GABRA5 {ECO:0000313|Ensembl:ENSP00000451527};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000451527, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000451527, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000451527}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; AC127511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC135999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC145167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC145196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EU606048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; G3V408; -.
DR   PeptideAtlas; G3V408; -.
DR   PRIDE; G3V408; -.
DR   Ensembl; ENST00000554038; ENSP00000451527; ENSG00000186297.
DR   UCSC; uc059gxo.1; human.
DR   EuPathDB; HostDB:ENSG00000186297.11; -.
DR   HGNC; HGNC:4079; GABRA5.
DR   OpenTargets; ENSG00000186297; -.
DR   eggNOG; KOG3642; Eukaryota.
DR   eggNOG; ENOG410XNQG; LUCA.
DR   GeneTree; ENSGT00940000156234; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000186297; Expressed in 85 organ(s), highest expression level in nucleus accumbens.
DR   ExpressionAtlas; G3V408; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR   GO; GO:0006821; P:chloride transport; IEA:InterPro.
DR   GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR001390; GABAAa_rcpt.
DR   InterPro; IPR005435; GABBAa5_rcpt.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   PRINTS; PR01079; GABAARALPHA.
DR   PRINTS; PR01618; GABAARALPHA5.
DR   SUPFAM; SSF63712; SSF63712; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:G3V408};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32     86       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003457296.
FT   NON_TER      86     86       {ECO:0000313|Ensembl:ENSP00000451527}.
SQ   SEQUENCE   86 AA;  9686 MW;  FFC9FF5C490BD2F2 CRC64;
     MDNGMFSGFI MIKNLLLFCI SMNLSSHFGF SQMPTSSVKD ETNDNITIFT RILDGLLDGY
     DNRLRPGLGE RITQVRTDIY VTSFGP
//