ID G3V3X5_HUMAN Unreviewed; 1777 AA. AC G3V3X5; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 13-FEB-2019, entry version 59. DE SubName: Full=Latent-transforming growth factor beta-binding protein 2 {ECO:0000313|Ensembl:ENSP00000451477}; GN Name=LTBP2 {ECO:0000313|Ensembl:ENSP00000451477}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000451477, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000451477, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12508121; DOI=10.1038/nature01348; RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., RA Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., RA Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., RA Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., RA Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., RA Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., RA Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., RA Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., RA Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., RA Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., RA Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., RA Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., RA Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., RA Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., RA Quetier F., Waterston R., Hood L., Weissenbach J.; RT "The DNA sequence and analysis of human chromosome 14."; RL Nature 421:601-607(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000451477} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC005479; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC013451; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; G3V3X5; -. DR SwissPalm; G3V3X5; -. DR jPOST; G3V3X5; -. DR PeptideAtlas; G3V3X5; -. DR PRIDE; G3V3X5; -. DR Ensembl; ENST00000556690; ENSP00000451477; ENSG00000119681. DR UCSC; uc059diw.1; human. DR EuPathDB; HostDB:ENSG00000119681.11; -. DR HGNC; HGNC:6715; LTBP2. DR OpenTargets; ENSG00000119681; -. DR eggNOG; ENOG410IR7H; Eukaryota. DR eggNOG; ENOG410XSTY; LUCA. DR GeneTree; ENSGT00940000160884; -. DR ChiTaRS; LTBP2; human. DR Proteomes; UP000005640; Chromosome 14. DR Bgee; ENSG00000119681; Expressed in 219 organ(s), highest expression level in tendon of biceps brachii. DR ExpressionAtlas; G3V3X5; baseline and differential. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR Gene3D; 3.90.290.10; -; 4. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR017878; TB_dom. DR InterPro; IPR036773; TB_dom_sf. DR Pfam; PF00008; EGF; 1. DR Pfam; PF07645; EGF_CA; 16. DR Pfam; PF00683; TB; 4. DR SMART; SM00181; EGF; 19. DR SMART; SM00179; EGF_CA; 17. DR SUPFAM; SSF57184; SSF57184; 4. DR SUPFAM; SSF57581; SSF57581; 4. DR PROSITE; PS00010; ASX_HYDROXYL; 12. DR PROSITE; PS00022; EGF_1; 2. DR PROSITE; PS01186; EGF_2; 9. DR PROSITE; PS50026; EGF_3; 15. DR PROSITE; PS01187; EGF_CA; 5. DR PROSITE; PS51364; TB; 4. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00032677}; KW Proteomics identification {ECO:0000213|MaxQB:G3V3X5, KW ECO:0000213|PeptideAtlas:G3V3X5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00594563}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 35 {ECO:0000256|SAM:SignalP}. FT CHAIN 36 1777 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003457133. FT DOMAIN 187 219 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 396 428 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 552 595 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 622 662 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 672 724 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 844 886 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 887 923 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 930 969 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1010 1050 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1135 1175 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1176 1217 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1218 1253 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1259 1300 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1367 1419 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 1441 1483 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1484 1519 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1540 1592 TB. {ECO:0000259|PROSITE:PS51364}. FT DOMAIN 1689 1725 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1730 1774 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DISULFID 191 201 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 209 218 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 400 410 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 418 427 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1488 1498 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 1777 AA; 190286 MW; EEEBF3877738D02A CRC64; MRPRTKARSP GRALRNPWRG FLPLTLALFV GAGHAQRDPV GRYEPAGGDA NRLRRPGGSY PAAAAAKVYS LFREQDAPVA GLQPVERAQP GWGSPRRPTE AEARRPSRAQ QSRRVQPPAQ TRRSTPLGQQ QPAPRTRAAP ALPRLGTPQR SGAAPPTPPR GRLTGRNVCG GQCCPGWTTA NSTNHCIKPV CEPPCQNRGS CSRPQLCVCR SGFRGARCEE VIPDEEFDPQ NSRLAPRRWA ERSPNLRRSS AAGEGTLARA QPPAPQSPPA PQSPPAGTLS GLSQTHPSQQ HVGLSRTVRL HPTATASSQL SSNALPPGPG LEQRDGTQQA VPLEHPSSPW GLNLTEKIKK IKIVFTPTIC KQTCARGHCA NSCERGDTTT LYSQGGHGHD PKSGFRIYFC QIPCLNGGRC IGRDECWCPA NSTGKFCHLP IPQPDREPPG RGSRPRALLE APLKQSTFTL PLSNQLASVN PSLVKVHIHH PPEASVQIHQ VAQVRGGVEE ALVENSVETR PPPWLPASPG HSLWDSNNIP ARSGEPPRPL PPAAPRPRGL LGRCYLNTVN GQCANPLLEL TTQEDCCGSV GAFWGVTLCA PCPPRPASPV IENGQLECPQ GYKRLNLTHC QDINECLTLG LCKDAECVNT RGSYLCTCRP GLMLDPSRSR CVSDKAISML QGLCYRSLGP GTCTLPLAQR ITKQICCCSR VGKAWGSECE KCPLPGTEAF REICPAGHGY TYASSDIRLS MRKAEEEELA RPPREQGQRS SGALPGPAER QPLRVVTDTW LEAGTIPDKG DSQAGQVTTS VTHAPAWVTG NATTPPMPEQ GIAEIQEEQV TPSTDVLVTL STPGIDRCAA GATNVCGPGT CVNLPDGYRC VCSPGYQLHP SQAYCTDDNE CLRDPCKGKG RCINRVGSYS CFCYPGYTLA TSGATQECQD INECEQPGVC SGGQCTNTEG SYHCECDQGY IMVRKGHCQD INECRHPGTC PDGRCVNSPG SYTCLACEEG YRGQSGSCVD VNECLTPGVC AHGKCTNLEG SFRCSCEQGY EVTSDEKGCQ DVDECASRAS CPTGLCLNTE GSFACSACEN GYWVNEDGTA CEDLDECAFP GVCPSGVCTN TAGSFSCKDC DGGYRPSPLG DSCEDVDECE DPQSSCLGGE CKNTVGSYQC LCPQGFQLAN GTVCEDVNEC MGEEHCAPHG ECLNSHGSFF CLCAPGFVSA EGGTSCQDVD ECATTDPCVG GHCVNTEGSF NCLCETGFQP SPESGECVDI DECANDTMCG SHGFCDNTDG SFRCLCDQGF EISPSGWDCV DVNECELMLA VCGAALCENV EGSFLCLCAS DLEEYDAQEG HCRPRGAGGQ SMSEAPTGDH APAPTRMDCY SGQKGHAPCS SVLGRNTTQA ECCCTQGASW GDACDLCPSE DSAEFSEICP SGKGYIPVEG AWTFGQTMYT DADECVIFGP GLCPNGRCLN TVPGYVCLCN PGFHYDASHK KCEDHDECQD LACENGECVN TEGSFHCFCS PPLTLDLSQQ RCMNSTSSTE DLPDHDIHMD ICWKKVTNDV CSEPLRGHRT TYTECCCQDG EAWSQQCALC PPRSSEVYAQ LCNVARIEAE REAGVHFRPG YEYGPGPDDL HYSIYGPDGA PFYNYLGPED TVPEPAFPNT AGHSADRTPI LESPLQPSEL QPHYVASHPE PPAGFEGLQA EECGILNGCE NGRCVRVREG YTCDCFEGFQ LDAAHMACVD VNECDDLNGP AVLCVHGYCE NTEGSYRCHC SPGYVAEAGP PHCTAKE //