ID   G3V381_HUMAN            Unreviewed;       112 AA.
AC   G3V381;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   05-DEC-2018, entry version 48.
DE   SubName: Full=Thyrotropin receptor {ECO:0000313|Ensembl:ENSP00000451092};
GN   Name=TSHR {ECO:0000313|Ensembl:ENSP00000451092};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000451092, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000451092, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000451092}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; AC007262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL136040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; G3V381; -.
DR   PeptideAtlas; G3V381; -.
DR   Ensembl; ENST00000555326; ENSP00000451092; ENSG00000165409.
DR   UCSC; uc059dyb.1; human.
DR   EuPathDB; HostDB:ENSG00000165409.15; -.
DR   HGNC; HGNC:12373; TSHR.
DR   OpenTargets; ENSG00000165409; -.
DR   eggNOG; KOG2087; Eukaryota.
DR   eggNOG; ENOG410XR1T; LUCA.
DR   GeneTree; ENSGT00940000156510; -.
DR   ChiTaRS; TSHR; human.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000165409; Expressed in 90 organ(s), highest expression level in left lobe of thyroid gland.
DR   ExpressionAtlas; G3V381; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0004996; F:thyroid-stimulating hormone receptor activity; IEA:InterPro.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002274; TSH_rcpt.
DR   InterPro; IPR034298; TSHR/LHCGR/FSHR.
DR   PANTHER; PTHR24372; PTHR24372; 1.
DR   PANTHER; PTHR24372:SF0; PTHR24372:SF0; 1.
DR   PRINTS; PR01145; TSHRECEPTOR.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:G3V381};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    112       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003457121.
SQ   SEQUENCE   112 AA;  12596 MW;  8773EF9DA3C57F18 CRC64;
     MRPADLLQLV LLLDLPRDLG GMGCSSPPCE CHQEEDFRVT CKDIQRIPSL PPSTQTLKLI
     ETHLRTIPSH AFSNLPNISR IYVSIDVTLQ QLESHSFYNL SKVTHITDTD AL
//