ID   G3V364_HUMAN            Unreviewed;       466 AA.
AC   G3V364;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   05-DEC-2018, entry version 60.
DE   SubName: Full=Leucine-rich repeat and fibronectin type-III domain-containing protein 5 {ECO:0000313|Ensembl:ENSP00000451067};
GN   Name=LRFN5 {ECO:0000313|Ensembl:ENSP00000451067};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000451067, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000451067, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000451067}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; AL109662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL121821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL138498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001317035.1; NM_001330106.1.
DR   RefSeq; NP_001333104.1; NM_001346175.1.
DR   UniGene; Hs.136893; -.
DR   ProteinModelPortal; G3V364; -.
DR   PeptideAtlas; G3V364; -.
DR   PRIDE; G3V364; -.
DR   Ensembl; ENST00000554171; ENSP00000451067; ENSG00000165379.
DR   GeneID; 145581; -.
DR   UCSC; uc010ana.5; human.
DR   CTD; 145581; -.
DR   EuPathDB; HostDB:ENSG00000165379.13; -.
DR   HGNC; HGNC:20360; LRFN5.
DR   OpenTargets; ENSG00000165379; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   eggNOG; COG4886; LUCA.
DR   GeneTree; ENSGT00940000158296; -.
DR   ChiTaRS; LRFN5; human.
DR   GenomeRNAi; 145581; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000165379; Expressed in 138 organ(s), highest expression level in middle temporal gyrus.
DR   ExpressionAtlas; G3V364; baseline and differential.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR026879; Lrfn5.
DR   InterPro; IPR026906; LRR_5.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR24373:SF3; PTHR24373:SF3; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF13306; LRR_5; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00369; LRR_TYP; 6.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51450; LRR; 6.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS01003558};
KW   Leucine-rich repeat {ECO:0000256|SAAS:SAAS01000947};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:G3V364};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00619387};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    466       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003457118.
FT   DOMAIN      287    373       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   466 AA;  52096 MW;  BE4C8467AE26A4A1 CRC64;
     MEKILFYLFL IGIAVKAQIC PKRCVCQILS PNLATLCAKK GLLFVPPNID RRTVELRLAD
     NFVTNIKRKD FANMTSLVDL TLSRNTISFI TPHAFADLRN LRALHLNSNR LTKITNDMFS
     GLSNLHHLIL NNNQLTLISS TAFDDVFALE ELDLSYNNLE TIPWDAVEKM VSLHTLSLDH
     NMIDNIPKGT FSHLHKMTRL DVTSNKLQKL PPDPLFQRAQ VLATSGIISP STFALSFGGN
     PLHCNCELLW LRRLSREDDL ETCASPPLLT GRYFWSIPEE EFLCEPPLIT RHTHEMRVLE
     GQRATLRCKA RGDPEPAIHW ISPEGKLISN ATRSLVYDNG TLDILITTVK DTGAFTCIAS
     NPAGEATQIV DLHIIKLPHL LNSTNHIHEP DPGSSDISTS TKSGSNTSSS NGDTKLSQDK
     IVVAEATSST ALLKFNFQRN IPGIRMFQIQ YNGTYDDTLV YRCFAD
//