ID G3V2U7_HUMAN Unreviewed; 129 AA. AC G3V2U7; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 16-JAN-2019, entry version 54. DE RecName: Full=Acylphosphatase {ECO:0000256|PROSITE-ProRule:PRU00520, ECO:0000256|RuleBase:RU000553}; DE EC=3.6.1.7 {ECO:0000256|PROSITE-ProRule:PRU00520, ECO:0000256|RuleBase:RU000553}; GN Name=ACYP1 {ECO:0000313|Ensembl:ENSP00000450873}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000450873, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000450873, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12508121; DOI=10.1038/nature01348; RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., RA Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., RA Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., RA Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., RA Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., RA Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., RA Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., RA Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., RA Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., RA Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., RA Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., RA Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., RA Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., RA Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., RA Quetier F., Waterston R., Hood L., Weissenbach J.; RT "The DNA sequence and analysis of human chromosome 14."; RL Nature 421:601-607(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000450873} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=an acyl phosphate + H2O = a carboxylate + H(+) + CC phosphate; Xref=Rhea:RHEA:14965, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:59918; EC=3.6.1.7; Evidence={ECO:0000256|PROSITE- CC ProRule:PRU00520, ECO:0000256|RuleBase:RU000553}; CC -!- SIMILARITY: Belongs to the acylphosphatase family. CC {ECO:0000256|RuleBase:RU004168}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL049780; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001289546.1; NM_001302617.1. DR UniGene; Hs.18573; -. DR ProteinModelPortal; G3V2U7; -. DR EPD; G3V2U7; -. DR jPOST; G3V2U7; -. DR MaxQB; G3V2U7; -. DR PeptideAtlas; G3V2U7; -. DR PRIDE; G3V2U7; -. DR Ensembl; ENST00000555463; ENSP00000450873; ENSG00000119640. DR GeneID; 97; -. DR UCSC; uc059dmk.1; human. DR CTD; 97; -. DR EuPathDB; HostDB:ENSG00000119640.8; -. DR HGNC; HGNC:179; ACYP1. DR OpenTargets; ENSG00000119640; -. DR eggNOG; KOG3360; Eukaryota. DR eggNOG; ENOG41126ER; LUCA. DR GeneTree; ENSGT00390000011103; -. DR OMA; DRANFSN; -. DR OrthoDB; 1502266at2759; -. DR ChiTaRS; ACYP1; human. DR GenomeRNAi; 97; -. DR Proteomes; UP000005640; Chromosome 14. DR Bgee; ENSG00000119640; Expressed in 218 organ(s), highest expression level in tendon. DR ExpressionAtlas; G3V2U7; baseline and differential. DR GO; GO:0003998; F:acylphosphatase activity; IEA:UniProtKB-EC. DR InterPro; IPR020456; Acylphosphatase. DR InterPro; IPR001792; Acylphosphatase-like_dom. DR InterPro; IPR036046; Acylphosphatase-like_dom_sf. DR InterPro; IPR017968; Acylphosphatase_CS. DR PANTHER; PTHR10029; PTHR10029; 1. DR Pfam; PF00708; Acylphosphatase; 1. DR PRINTS; PR00112; ACYLPHPHTASE. DR SUPFAM; SSF54975; SSF54975; 1. DR PROSITE; PS00150; ACYLPHOSPHATASE_1; 1. DR PROSITE; PS00151; ACYLPHOSPHATASE_2; 1. DR PROSITE; PS51160; ACYLPHOSPHATASE_3; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00520, KW ECO:0000256|RuleBase:RU000553}; KW Proteomics identification {ECO:0000213|EPD:G3V2U7, KW ECO:0000213|MaxQB:G3V2U7, ECO:0000213|PeptideAtlas:G3V2U7}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 129 Acylphosphatase. FT {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003457339. FT DOMAIN 39 129 Acylphosphatase-like. FT {ECO:0000259|PROSITE:PS51160}. FT ACT_SITE 54 54 {ECO:0000256|PROSITE-ProRule:PRU00520}. FT ACT_SITE 72 72 {ECO:0000256|PROSITE-ProRule:PRU00520}. SQ SEQUENCE 129 AA; 14125 MW; 49D17A620B0A3200 CRC64; MPASARLAGA GLLLAFLRAL GCAGRAPGLS MAEGNTLISV DYEIFGKVQG VFFRKHTQAE GKKLGLVGWV QNTDRGTVQG QLQGPISKVR HMQEWLETRG SPKSHIDKAN FNNEKVILKL DYSDFQIVK //