ID   G3V2T1_HUMAN            Unreviewed;       332 AA.
AC   G3V2T1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   16-JAN-2019, entry version 41.
DE   SubName: Full=Alpha-2,8-sialyltransferase 8B {ECO:0000313|Ensembl:ENSP00000450851};
DE   Flags: Fragment;
GN   Name=ST8SIA2 {ECO:0000313|Ensembl:ENSP00000450851};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000450851, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000450851, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000450851}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 29 family.
CC       {ECO:0000256|SAAS:SAAS01027238}.
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DR   EMBL; AC090985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC116162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; G3V2T1; -.
DR   jPOST; G3V2T1; -.
DR   PeptideAtlas; G3V2T1; -.
DR   PRIDE; G3V2T1; -.
DR   Ensembl; ENST00000555434; ENSP00000450851; ENSG00000140557.
DR   UCSC; uc059nlb.1; human.
DR   EuPathDB; HostDB:ENSG00000140557.11; -.
DR   HGNC; HGNC:10870; ST8SIA2.
DR   OpenTargets; ENSG00000140557; -.
DR   GeneTree; ENSGT00940000154058; -.
DR   ChiTaRS; ST8SIA2; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000140557; Expressed in 66 organ(s), highest expression level in brain.
DR   ExpressionAtlas; G3V2T1; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008373; F:sialyltransferase activity; IEA:InterPro.
DR   GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR   Gene3D; 3.90.1480.20; -; 1.
DR   InterPro; IPR001675; Glyco_trans_29.
DR   InterPro; IPR038578; GT29-like_sf.
DR   InterPro; IPR012163; Sialyl_trans.
DR   Pfam; PF00777; Glyco_transf_29; 1.
DR   PIRSF; PIRSF005557; Sialyl_trans; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Glycosyltransferase {ECO:0000256|SAAS:SAAS01027230};
KW   Golgi apparatus {ECO:0000256|SAAS:SAAS01027226};
KW   Membrane {ECO:0000256|SAAS:SAAS01027233};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS01027230};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01027233};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01027233}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    332       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003456742.
FT   DISULFID    114    264       {ECO:0000256|PIRSR:PIRSR005557-2}.
FT   NON_TER     332    332       {ECO:0000313|Ensembl:ENSP00000450851}.
SQ   SEQUENCE   332 AA;  37665 MW;  C4F4C17F0D13BD4B CRC64;
     MQLQFRSWML AALTLLVVFL IFADISEIEE EIGNSGGRGT IRSAVNSLHS KSNRKQILKF
     LDAEKDISVL KGTLKPGDII HYIFDRDSTM NVSQNLYELL PRTSPLKNKH FGTCAIVGNS
     GVLLNSGCGQ EIDAHSFVIR CNLAPVQEYA RDVGLKTDLV TMNPSVIQRA FEDLVNATWR
     EKLLQRLHSL NGSILWIPAF MARGGKERVE WVNELILKHH VNVRTAYPSL RLLHAVRGYW
     LTNKVHIKRP TTGLLMYTLA TRFCKQIYLY GFWPFPLDQN QNPVKYHYYD SLKYGYTSQA
     SPHTMPLEFK ALKSLHEQGA LKLTVGQCDG AT
//