ID   G0XQ39_HUMAN            Unreviewed;       791 AA.
AC   G0XQ39;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   16-JAN-2019, entry version 61.
DE   SubName: Full=STIM1L {ECO:0000313|EMBL:ADO20317.1};
DE   SubName: Full=Stromal interaction molecule 1 {ECO:0000313|Ensembl:ENSP00000478059};
GN   Name=STIM1 {ECO:0000313|EMBL:ADO20317.1,
GN   ECO:0000313|Ensembl:ENSP00000478059};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ADO20317.1};
RN   [1] {ECO:0000213|PubMed:17081983}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA   Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in
RT   signaling networks.";
RL   Cell 127:635-648(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000478059, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3] {ECO:0000213|PubMed:18088087}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18088087; DOI=10.1021/pr0704130;
RA   Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,
RA   Schutz C., Walter U., Gambaryan S., Sickmann A.;
RT   "Phosphoproteome of resting human platelets.";
RL   J. Proteome Res. 7:526-534(2008).
RN   [4] {ECO:0000213|PubMed:19367720}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19367720; DOI=10.1021/pr800500r;
RA   Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.;
RT   "Phosphorylation analysis of primary human T lymphocytes using
RT   sequential IMAC and titanium oxide enrichment.";
RL   J. Proteome Res. 7:5167-5176(2008).
RN   [5] {ECO:0000213|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [6] {ECO:0000213|PubMed:19690332}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:ra46-RA46(2009).
RN   [7] {ECO:0000213|PubMed:20068231}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA   Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full
RT   phosphorylation site occupancy during mitosis.";
RL   Sci. Signal. 3:ra3-RA3(2010).
RN   [8] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [9] {ECO:0000313|EMBL:ADO20317.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21788372; DOI=10.1083/jcb.201012157;
RA   Darbellay B., Arnaudeau S., Bader C.R., Konig S., Bernheim L.;
RT   "STIM1L is a new actin-binding splice variant involved in fast
RT   repetitive Ca2+ release.";
RL   J. Cell Biol. 194:335-346(2011).
RN   [10] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [11] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [12] {ECO:0000313|Ensembl:ENSP00000478059}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
RN   [13] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC015689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC087441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC107970; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; HQ317451; ADO20317.1; -; mRNA.
DR   RefSeq; NP_001264890.1; NM_001277961.1.
DR   RefSeq; NP_001264891.1; NM_001277962.1.
DR   UniGene; Hs.501735; -.
DR   UniGene; Hs.657794; -.
DR   SMR; G0XQ39; -.
DR   EPD; G0XQ39; -.
DR   jPOST; G0XQ39; -.
DR   PeptideAtlas; G0XQ39; -.
DR   PRIDE; G0XQ39; -.
DR   Ensembl; ENST00000616714; ENSP00000478059; ENSG00000167323.
DR   GeneID; 6786; -.
DR   UCSC; uc021qco.1; human.
DR   CTD; 6786; -.
DR   EuPathDB; HostDB:ENSG00000167323.9; -.
DR   HGNC; HGNC:11386; STIM1.
DR   OpenTargets; ENSG00000167323; -.
DR   eggNOG; KOG4403; Eukaryota.
DR   eggNOG; ENOG410XRM6; LUCA.
DR   GeneTree; ENSGT00390000000214; -.
DR   OMA; FDPFRFG; -.
DR   OrthoDB; 373308at2759; -.
DR   ChiTaRS; STIM1; human.
DR   GenomeRNAi; 6786; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000167323; Expressed in 192 organ(s), highest expression level in gastrocnemius.
DR   ExpressionAtlas; G0XQ39; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
DR   GO; GO:0030426; C:growth cone; IEA:Ensembl.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0032237; P:activation of store-operated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0014902; P:myotube differentiation; IEA:Ensembl.
DR   GO; GO:2001256; P:regulation of store-operated calcium entry; IEA:Ensembl.
DR   GO; GO:0002115; P:store-operated calcium entry; IEA:Ensembl.
DR   CDD; cd09573; SAM_STIM1; 1.
DR   CDD; cd11722; SOAR; 1.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR032393; SOAR.
DR   InterPro; IPR037608; STIM.
DR   InterPro; IPR037609; STIM1_SAM.
DR   InterPro; IPR030463; STM1.
DR   PANTHER; PTHR15136; PTHR15136; 2.
DR   PANTHER; PTHR15136:SF9; PTHR15136:SF9; 2.
DR   Pfam; PF07647; SAM_2; 1.
DR   Pfam; PF16533; SOAR; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:G0XQ39,
KW   ECO:0000213|MaxQB:G0XQ39, ECO:0000213|PeptideAtlas:G0XQ39};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    791       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014091417.
FT   TRANSMEM    214    232       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      132    190       SAM. {ECO:0000259|PROSITE:PS50105}.
FT   COILED      251    310       {ECO:0000256|SAM:Coils}.
FT   COILED      314    341       {ECO:0000256|SAM:Coils}.
FT   COILED      366    386       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   791 AA;  88646 MW;  C9D294979342EAEA CRC64;
     MDVCVRLALW LLWGLLLHQG QSLSHSHSEK ATGTSSGANS EESTAAEFCR IDKPLCHSED
     EKLSFEAVRN IHKLMDDDAN GDVDVEESDE FLREDLNYHD PTVKHSTFHG EDKLISVEDL
     WKAWKSSEVY NWTVDEVVQW LITYVELPQY EETFRKLQLS GHAMPRLAVT NTTMTGTVLK
     MTDRSHRQKL QLKALDTVLF GPPLLTRHNH LKDFMLVVSI VIGVGGCWFA YIQNRYSKEH
     MKKMMKDLEG LHRAEQSLHD LQERLHKAQE EHRTVEVEKV HLEKKLRDEI NLAKQEAQRL
     KELREGTENE RSRQKYAEEE LEQVREALRK AEKELESHSS WYAPEALQKW LQLTHEVEVQ
     YYNIKKQNAE KQLLVAKEGA EKIKKKRNTL FGTFHVAHSS SLDDVDHKIL TAKQALSEVT
     AALRERLHRW QQIEILCGFQ IVNNPGIHSL VAALNIDPSW MGSTRPNPAH FIMTDDVDDM
     DEEIVSPLSM QSPSLQSSVR QRLTEPQHGL GSQRLVEGEA GHFLTSRVSL RRMRSLSSGQ
     SFSSEGYGTS SPSASAAASC SSSITTITTT TTTTTTFTTV HVHPVYYHHS TSYFLQMEPY
     PDTPPSDSTA VMPGHSESLG DLTHSDSESS LHMSDRQRVA PKPPQMSRAA DEALNAMTSN
     GSHRLIEGVH PGSLVEKLPD SPALAKKALL ALNHGLDKAH SLMELSPSAP PGGSPHLDSS
     RSHSPSSPDP DTPSPVGDSR ALQASRNTRI PHLAGKKAVA EEDNGSIGEE TDSSPGRKKF
     PLKIFKKPLK K
//