ID   F8WEY4_HUMAN            Unreviewed;       146 AA.
AC   F8WEY4;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   05-DEC-2018, entry version 54.
DE   RecName: Full=Claudin {ECO:0000256|RuleBase:RU060637};
GN   Name=CLDN18 {ECO:0000313|Ensembl:ENSP00000419732};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000419732, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000419732, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000419732}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Plays a major role in tight junction-specific
CC       obliteration of the intercellular space, through calcium-
CC       independent cell-adhesion activity.
CC       {ECO:0000256|RuleBase:RU060637}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|SAAS:SAAS00567644}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00567644}.
CC   -!- SIMILARITY: Belongs to the claudin family.
CC       {ECO:0000256|RuleBase:RU060637, ECO:0000256|SAAS:SAAS00567656}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU060637}.
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DR   EMBL; AC016252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F8WEY4; -.
DR   PeptideAtlas; F8WEY4; -.
DR   PRIDE; F8WEY4; -.
DR   Ensembl; ENST00000479660; ENSP00000419732; ENSG00000066405.
DR   UCSC; uc062oeu.1; human.
DR   EuPathDB; HostDB:ENSG00000066405.12; -.
DR   HGNC; HGNC:2039; CLDN18.
DR   OpenTargets; ENSG00000066405; -.
DR   eggNOG; ENOG410IG28; Eukaryota.
DR   eggNOG; ENOG410XPD1; LUCA.
DR   GeneTree; ENSGT00940000158655; -.
DR   ChiTaRS; CLDN18; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000066405; Expressed in 115 organ(s), highest expression level in pylorus.
DR   ExpressionAtlas; F8WEY4; baseline and differential.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-UniRule.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR006187; Claudin.
DR   InterPro; IPR003928; Claudin18.
DR   InterPro; IPR017974; Claudin_CS.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR12002; PTHR12002; 1.
DR   PANTHER; PTHR12002:SF9; PTHR12002:SF9; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01448; CLAUDIN18.
DR   PROSITE; PS01346; CLAUDIN; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455883};
KW   Cell membrane {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455877};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455877, ECO:0000256|SAAS:SAAS00463381};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Tight junction {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455883};
KW   Transmembrane {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00463381};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00463381}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    146       Claudin. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003385543.
FT   TRANSMEM     81    101       Helical. {ECO:0000256|RuleBase:RU060637}.
SQ   SEQUENCE   146 AA;  15679 MW;  4B2903CD9728C76A CRC64;
     MSTTTCQVVA FLLSILGLAG CIAATGMDMW STQDLYDNPV TSVFQYEGLW RSCVRQSSGF
     TECRPYFTIL GLPAMLQAVR ALMIVGIVLG AIGLLVSIFA LKCIRIGSME DSAKANMTLT
     SGIMFIVSGT HLVRLCSWAG SLEASH
//