ID   F8WE85_HUMAN            Unreviewed;      1335 AA.
AC   F8WE85;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   16-JAN-2019, entry version 50.
DE   SubName: Full=FRAS1-related extracellular matrix protein 1 {ECO:0000313|Ensembl:ENSP00000370257};
GN   Name=FREM1 {ECO:0000313|Ensembl:ENSP00000370257};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000370257, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000370257, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000370257}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AL354672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL390732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL512643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; F8WE85; -.
DR   PeptideAtlas; F8WE85; -.
DR   PRIDE; F8WE85; -.
DR   Ensembl; ENST00000380875; ENSP00000370257; ENSG00000164946.
DR   UCSC; uc064seo.1; human.
DR   EuPathDB; HostDB:ENSG00000164946.19; -.
DR   HGNC; HGNC:23399; FREM1.
DR   OpenTargets; ENSG00000164946; -.
DR   eggNOG; ENOG410IR0E; Eukaryota.
DR   eggNOG; ENOG410ZHZ2; LUCA.
DR   GeneTree; ENSGT00940000156990; -.
DR   ChiTaRS; FREM1; human.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000164946; Expressed in 122 organ(s), highest expression level in kidney.
DR   ExpressionAtlas; F8WE85; baseline and differential.
DR   GO; GO:0005604; C:basement membrane; IEA:InterPro.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR   InterPro; IPR039005; CSPG_rpt.
DR   InterPro; IPR032825; FREM1.
DR   PANTHER; PTHR11878:SF24; PTHR11878:SF24; 1.
DR   PROSITE; PS51854; CSPG; 9.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:F8WE85,
KW   ECO:0000213|PeptideAtlas:F8WE85};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22   1335       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003385527.
FT   REPEAT      296    390       CSPG. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01201}.
FT   REPEAT      413    500       CSPG. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01201}.
FT   REPEAT      521    615       CSPG. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01201}.
FT   REPEAT      642    754       CSPG. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01201}.
FT   REPEAT      776    867       CSPG. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01201}.
FT   REPEAT      887    982       CSPG. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01201}.
FT   REPEAT     1024   1126       CSPG. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01201}.
FT   REPEAT     1147   1254       CSPG. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01201}.
FT   REPEAT     1275   1335       CSPG. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01201}.
SQ   SEQUENCE   1335 AA;  149463 MW;  86FDAFB752FF0C92 CRC64;
     MNSLSWGAAN AVLLLLLLAW ASPTFISINR GVRVMKGHSA FLSGDDLKFA IPKEKDACKV
     EVVMNEPITQ RVGKLTPQVF DCHFLPNEVK YVHNGCPILD EDTVKLRLYR FTERDTFIET
     FILWVYLLEP DCNIIHMSNN VLEVPEFNGL SQAIDKNLLR FDYDRMASLE CTVSLDTART
     RLPAHGQMVL GEPRPEEPRG DQPHSFFPES QLRAKLKCPG GSCTPGLKKI GSLKVSCEEF
     LLMGLRYQHL DPPSPNIDYI SIQLDLTDTR SKIVYKSESA WLPVYIRAGI PNQIPKAAFM
     AVFILEVDQF ILTSLTTSVL DCEEDETPKP LLVFNITKAP LQGYVTHLLD HTRPISSFTW
     KDLSDMQIAY QPPNSSHSER RHDEVELEVY DFFFERSAPM TVHISIRTAD TNAPRVSWNT
     GLSLLEGQSR AITWEQFQVV DNDDIGAVRL VTVGGLQHGW LTLRGGKGFL FTVADLQAGV
     VRYHHDDSDS TKDFVVFRIF DGHHSIRHKF PINVLPKDDS PPFLITNVVI ELEEGQTILI
     QGSMLRASDV DASDDYIFFN ITKPPQAGEI MKKPGPGLIG YPVHGFLQRD LFNGIIYYRH
     FGGEIFEDSF QFVLWDSHEP PNLSVPQVAT IHITPVDDQL PKEAPGVSRH LVVKETEVAY
     ITKKQLHFID SESYDRELVY TITTPPFFSF SHRHLDAGKL FMVDSIPKVV KNPTALELRS
     FTQHAVNYMK VAYMPPMQDI GPHCRDVQFT FSVSNQHGGT LHGICFNITI LPVDNQVPEA
     FTNPLKVTEG GQSIISTEHI LISDADTKLD NIDLSLRELP LHGRVELNGF PLNSGGTFSW
     GDLHTLKVRY QHDGTEVLQD DLLLEVTDGT NSAEFVLHVE VFPVNDEPPV LKADLMPVMN
     CSEGGEVVIT SEYIFATDVD SDNLKLMFVI AREPQHGVVR RAGVTVDQFS QRDVISEAVT
     YKHTGGEIGL MPCFDTITLV VSDGEAGPFV NGCCYNGPNP SVPLHASFPV YDLNITVYPV
     DNQPPSIAIG PVFVVDEGCS TALTVNHLSA TDPDTAADDL EFVLVSPPQF GYLENILPSV
     GFEKSNIGIS IDSFQWKDMN AFHINYVQSR HLRIEPTADQ FTVYVTDGKH HSLEIPFSII
     INPTNDEAPD FVVQNITVCE GQMKELDSSI ISAVDLDIPQ DALLFSITQK PRHGLLIDRG
     FSKDFSENKQ PANPHQKHAP VHSFSMELLK TGMRLTYMHD DSESLADDFT IQLSDGKHKI
     LKTISVEVIP VNDEKPMLSK KAEIAMNMGE TRIISSAILS AIDEDSPREK IYYVFERLPQ
     NGQLQLKECQ LRCGI
//