ID   F8WDW9_HUMAN            Unreviewed;       245 AA.
AC   F8WDW9;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   SubName: Full=Endothelial cell-selective adhesion molecule {ECO:0000313|Ensembl:ENSP00000389235};
GN   Name=ESAM {ECO:0000313|Ensembl:ENSP00000389235};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000389235, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000389235, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000389235}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP000866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F8WDW9; -.
DR   SMR; F8WDW9; -.
DR   jPOST; F8WDW9; -.
DR   MaxQB; F8WDW9; -.
DR   PeptideAtlas; F8WDW9; -.
DR   PRIDE; F8WDW9; -.
DR   Ensembl; ENST00000417453; ENSP00000389235; ENSG00000149564.
DR   UCSC; uc058iri.1; human.
DR   EuPathDB; HostDB:ENSG00000149564.11; -.
DR   HGNC; HGNC:17474; ESAM.
DR   OpenTargets; ENSG00000149564; -.
DR   eggNOG; ENOG410IHVB; Eukaryota.
DR   eggNOG; ENOG4111DT8; LUCA.
DR   GeneTree; ENSGT00940000157231; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000149564; Expressed in 178 organ(s), highest expression level in prostate gland.
DR   ExpressionAtlas; F8WDW9; baseline and differential.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:F8WDW9,
KW   ECO:0000213|PeptideAtlas:F8WDW9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30    245       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003385519.
FT   DOMAIN       26    143       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      167    242       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   245 AA;  26701 MW;  27123A1F35F997CD CRC64;
     MISLPGPLVT NLLRFLFLGL SALAPPSRAQ LQLHLPANRL QAVEGGEVVL PAWYTLHGEV
     SSSQPWEVPF VMWFFKQKEK EDQVLSYING VTTSKPGVSL VYSMPSRNLS LRLEGLQEKD
     SGPYSCSVNV QDKQGKSRGH SIKTLELNVL VPPAPPSCRL QGVPHVGANV TLSCQSPRSK
     PAVQYQWDRQ LPSFQTFFAP ALDVIRGSLS LTNLSSSMAG VYVCKAHNEV GTAQCNVTLE
     VSTGQ
//