ID   F8WDI9_HUMAN            Unreviewed;       176 AA.
AC   F8WDI9;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   16-JAN-2019, entry version 58.
DE   SubName: Full=Transducin beta-like protein 2 {ECO:0000313|Ensembl:ENSP00000409820};
GN   Name=TBL2 {ECO:0000313|Ensembl:ENSP00000409820};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000409820, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000409820, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000409820}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC005089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F8WDI9; -.
DR   jPOST; F8WDI9; -.
DR   MaxQB; F8WDI9; -.
DR   PeptideAtlas; F8WDI9; -.
DR   PRIDE; F8WDI9; -.
DR   Ensembl; ENST00000450285; ENSP00000409820; ENSG00000106638.
DR   UCSC; uc064eew.1; human.
DR   EuPathDB; HostDB:ENSG00000106638.15; -.
DR   HGNC; HGNC:11586; TBL2.
DR   OpenTargets; ENSG00000106638; -.
DR   eggNOG; KOG2096; Eukaryota.
DR   eggNOG; COG2319; LUCA.
DR   GeneTree; ENSGT00390000013836; -.
DR   SignaLink; F8WDI9; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000106638; Expressed in 228 organ(s), highest expression level in testis.
DR   ExpressionAtlas; F8WDI9; baseline and differential.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:F8WDI9,
KW   ECO:0000213|MaxQB:F8WDI9, ECO:0000213|PeptideAtlas:F8WDI9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31    176       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003379689.
FT   DOMAIN       86    127       WD_REPEATS_REGION.
FT                                {ECO:0000259|PROSITE:PS50294}.
FT   REPEAT       86    118       WD. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00221}.
SQ   SEQUENCE   176 AA;  19572 MW;  06E95315E49C20B9 CRC64;
     MELSQMSELM GLSVLLGLLA LMATAAVARG WLRAGEERSG RPACQKANGF PPDKSSGSKK
     QKQYQRIRKE KPQQHNFTHR LLAAALKSHS GNISCMDFSS NGKYLATCAD DRTIRIWSTK
     DFLQREHRSM RANVELDHAT LSLHRLAGQR GHPPCLQDDQ AGGWGLHLHS HPRGLP
//