ID   F8WDG5_HUMAN            Unreviewed;       281 AA.
AC   F8WDG5;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   05-DEC-2018, entry version 52.
DE   SubName: Full=Ephrin type-B receptor 1 {ECO:0000313|Ensembl:ENSP00000420338};
GN   Name=EPHB1 {ECO:0000313|Ensembl:ENSP00000420338};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000420338, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000420338, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000420338}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC016931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC016951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC063918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC073244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC092969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC109912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F8WDG5; -.
DR   MaxQB; F8WDG5; -.
DR   PeptideAtlas; F8WDG5; -.
DR   PRIDE; F8WDG5; -.
DR   Ensembl; ENST00000482618; ENSP00000420338; ENSG00000154928.
DR   UCSC; uc062och.1; human.
DR   EuPathDB; HostDB:ENSG00000154928.16; -.
DR   HGNC; HGNC:3392; EPHB1.
DR   OpenTargets; ENSG00000154928; -.
DR   eggNOG; KOG0196; Eukaryota.
DR   eggNOG; COG0515; LUCA.
DR   GeneTree; ENSGT00940000155297; -.
DR   ChiTaRS; EPHB1; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000154928; Expressed in 153 organ(s), highest expression level in neocortex.
DR   ExpressionAtlas; F8WDG5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0005003; F:ephrin receptor activity; IEA:InterPro.
DR   CDD; cd10476; EphR_LBD_B1; 1.
DR   Gene3D; 2.60.120.260; -; 1.
DR   InterPro; IPR034231; EphB1_rcpt_lig-bd.
DR   InterPro; IPR001090; Ephrin_rcpt_lig-bd_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR001426; Tyr_kinase_rcpt_V_CS.
DR   Pfam; PF01404; Ephrin_lbd; 1.
DR   SMART; SM00615; EPH_lbd; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   PROSITE; PS51550; EPH_LBD; 1.
DR   PROSITE; PS00790; RECEPTOR_TYR_KIN_V_1; 1.
DR   PROSITE; PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:F8WDG5,
KW   ECO:0000213|PeptideAtlas:F8WDG5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    281       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003379463.
FT   DOMAIN       19    201       Eph LBD. {ECO:0000259|PROSITE:PS51550}.
SQ   SEQUENCE   281 AA;  31630 MW;  0B5E710108FF9A6E CRC64;
     MALDYLLLLL LASAVAAMEE TLMDTRTATA ELGWTANPAS GWEEVSGYDE NLNTIRTYQV
     CNVFEPNQNN WLLTTFINRR GAHRIYTEMR FTVRDCSSLP NVPGSCKETF NLYYYETDSV
     IATKKSAFWS EAPYLKVDTI AADESFSQVD FGGRLMKVNT EVRSFGPLTR NGFYLAFQDY
     GACMSLLSVR VFFKKCPSIV QNFAVFPETM TGAESTSLVI ARGTCIPNAE EVDVPIKLYC
     NGDGEWMVPI GRCTCKPGYE PENSVACKVS RPFWRILRQQ D
//