ID   F8WCM8_HUMAN            Unreviewed;      1022 AA.
AC   F8WCM8;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   16-JAN-2019, entry version 67.
DE   SubName: Full=Ephrin type-B receptor 6 {ECO:0000313|Ensembl:ENSP00000404786};
GN   Name=EPHB6 {ECO:0000313|Ensembl:ENSP00000404786};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000404786, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000404786, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000404786}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000481994}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC245427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_004436.4; NM_004445.5.
DR   RefSeq; XP_006715944.1; XM_006715881.2.
DR   RefSeq; XP_011514181.1; XM_011515879.1.
DR   RefSeq; XP_011514182.1; XM_011515880.1.
DR   UniGene; Hs.380089; -.
DR   SMR; F8WCM8; -.
DR   jPOST; F8WCM8; -.
DR   Ensembl; ENST00000422643; ENSP00000404786; ENSG00000106123.
DR   Ensembl; ENST00000619012; ENSP00000481994; ENSG00000106123.
DR   GeneID; 2051; -.
DR   KEGG; hsa:2051; -.
DR   UCSC; uc033ans.2; human.
DR   CTD; 2051; -.
DR   EuPathDB; HostDB:ENSG00000106123.11; -.
DR   HGNC; HGNC:3396; EPHB6.
DR   OpenTargets; ENSG00000106123; -.
DR   eggNOG; KOG0196; Eukaryota.
DR   eggNOG; COG0515; LUCA.
DR   GeneTree; ENSGT00940000160399; -.
DR   KO; K05114; -.
DR   OMA; FSKFGLC; -.
DR   OrthoDB; 933071at2759; -.
DR   ChiTaRS; EPHB6; human.
DR   GenomeRNAi; 2051; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000106123; Expressed in 193 organ(s), highest expression level in anterior cingulate cortex.
DR   ExpressionAtlas; F8WCM8; baseline and differential.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005003; F:ephrin receptor activity; IEA:InterPro.
DR   GO; GO:0050798; P:activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0050663; P:cytokine secretion; IEA:Ensembl.
DR   GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
DR   GO; GO:2000525; P:positive regulation of T cell costimulation; IEA:Ensembl.
DR   GO; GO:0001806; P:type IV hypersensitivity; IEA:Ensembl.
DR   CDD; cd00063; FN3; 2.
DR   Gene3D; 2.60.120.260; -; 1.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR027936; Eph_TM.
DR   InterPro; IPR001090; Ephrin_rcpt_lig-bd_dom.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR   InterPro; IPR016257; Tyr_kinase_ephrin_rcpt.
DR   InterPro; IPR001426; Tyr_kinase_rcpt_V_CS.
DR   Pfam; PF14575; EphA2_TM; 1.
DR   Pfam; PF01404; Ephrin_lbd; 1.
DR   Pfam; PF07699; Ephrin_rec_like; 1.
DR   Pfam; PF00041; fn3; 2.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF07647; SAM_2; 1.
DR   PIRSF; PIRSF000666; TyrPK_ephrin_receptor; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00615; EPH_lbd; 1.
DR   SMART; SM01411; Ephrin_rec_like; 1.
DR   SMART; SM00060; FN3; 2.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS51550; EPH_LBD; 1.
DR   PROSITE; PS50853; FN3; 2.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00790; RECEPTOR_TYR_KIN_V_1; 1.
DR   PROSITE; PS00791; RECEPTOR_TYR_KIN_V_2; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR000666-2,
KW   ECO:0000256|SAAS:SAAS00461464};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00782428, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000666-2,
KW   ECO:0000256|SAAS:SAAS00461464};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:F8WCM8};
KW   Receptor {ECO:0000256|SAAS:SAAS00786465};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS01054641};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00782428,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00782428,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32   1022       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014571689.
FT   TRANSMEM    596    620       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       33    238       Eph LBD. {ECO:0000259|PROSITE:PS51550}.
FT   DOMAIN      370    487       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      488    583       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      671    920       Protein kinase.
FT                                {ECO:0000259|PROSITE:PS50011}.
FT   DOMAIN      957   1013       SAM. {ECO:0000259|PROSITE:PS50105}.
FT   NP_BIND     677    685       ATP. {ECO:0000256|PIRSR:PIRSR000666-2}.
SQ   SEQUENCE   1022 AA;  110771 MW;  5038EA11DEE6FFCE CRC64;
     MATEGAAQLG NRVAGMVCSL WVLLLVSSVL ALEEVLLDTT GETSEIGWLT YPPGGWDEVS
     VLDDQRRLTR TFEACHVAGA PPGTGQDNWL QTHFVERRGA QRAHIRLHFS VRACSSLGVS
     GGTCRETFTL YYRQAEEPDS PDSVSSWHLK RWTKVDTIAA DESFPSSSSS SSSSSSSAAW
     AVGPHGAGQR AGLQLNVKER SFGPLTQRGF YVAFQDTGAC LALVAVRLFS YTCPAVLRSF
     ASFPETQASG AGGASLVAAV GTCVAHAEPE EDGVGGQAGG SPPRLHCNGE GKWMVAVGGC
     RCQPGYQPAR GDKACQACPR GLYKASAGNA PCSPCPARSH APNPAAPVCP CLEGFYRASS
     DPPEAPCTGP PSAPQELWFE VQGSALMLHW RLPRELGGRG DLLFNVVCKE CEGRQEPASG
     GGGTCHRCRD EVHFDPRQRG LTESRVLVGG LRAHVPYILE VQAVNGVSEL SPDPPQAAAI
     NVSTSHEVPS AVPVVHQVSR ASNSITVSWP QPDQTNGNIL DYQLRYYDQA EDESHSFTLT
     SETNTATVTQ LSPGHIYGFQ VRARTAAGHG PYGGKVYFQT LPQGELSSQL PERLSLVIGS
     ILGALAFLLL AAITVLAVVF QRKRRGTGYT EQLQQYSSPG LGVKYYIDPS TYEDPCQAIR
     ELAREVDPAY IKIEEVIGTG SFGEVRQGRL QPRGRREQTV AIQALWAGGA ESLQMTFLGR
     AAVLGQFQHP NILRLEGVVT KSRPLMVLTE FMELGPLDSF LRQREGQFSS LQLVAMQRGV
     AAAMQYLSSF AFVHRSLSAH SVLVNSHLVC KVARLGHSPQ GPSCLLRWAA PEVIAHGKHT
     TSSDVWSFGI LMWEVMSYGE RPYWDMSEQE VLNAIEQEFR LPPPPGCPPG LHLLMLDTWQ
     KDRARRPHFD QLVAAFDKMI RKPDTLQAGG DPGERPSQAL LTPVALDFPC LDSPQAWLSA
     IGLECYQDNF SKFGLCTFSD VAQLSLEDLP ALGITLAGHQ KKLLHHIQLL QQHLRQQGSV
     EV
//