ID   F8WC24_HUMAN            Unreviewed;       237 AA.
AC   F8WC24;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   13-FEB-2019, entry version 53.
DE   SubName: Full=Cellular communication network factor 6 {ECO:0000313|Ensembl:ENSP00000357653};
GN   Name=CCN6 {ECO:0000313|Ensembl:ENSP00000357653};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000357653, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000357653, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000357653}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AL512299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; Z99289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F8WC24; -.
DR   PeptideAtlas; F8WC24; -.
DR   PRIDE; F8WC24; -.
DR   Ensembl; ENST00000368664; ENSP00000357653; ENSG00000112761.
DR   UCSC; uc063qta.1; human.
DR   EuPathDB; HostDB:ENSG00000112761.18; -.
DR   HGNC; HGNC:12771; CCN6.
DR   OpenTargets; ENSG00000112761; -.
DR   eggNOG; ENOG410IJZE; Eukaryota.
DR   eggNOG; ENOG4110BH0; LUCA.
DR   GeneTree; ENSGT00940000160119; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000112761; Expressed in 90 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; F8WC24; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR000867; IGFBP-like.
DR   InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR   Pfam; PF00219; IGFBP; 1.
DR   SMART; SM00121; IB; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00222; IGFBP_N_1; 1.
DR   PROSITE; PS51323; IGFBP_N_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     33       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        34    237       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003379446.
FT   DOMAIN       62    135       IGFBP N-terminal.
FT                                {ECO:0000259|PROSITE:PS51323}.
SQ   SEQUENCE   237 AA;  25660 MW;  310996DB98C577FB CRC64;
     MNKRRLLYPS GWLHGPSDMQ GLLFSTLLLA GLAQFCCRVQ GTGPLDTTPE GRPGEVSDAP
     QRKQFCHWPC KCPQQKPRCP PGVSLVRDGC GCCKICAKQP GEICNEADLC DPHKGLYCDY
     SVDRPRYETG VCAYLVAVGC EFNQVHYHNG QVFQPNPLFS CLCVSGAIGC TPLFIPKLAG
     SHCSGAKGGK KSDQSNCSLE PLLQQLSTSY KTMPDVCQAS NLLPALRSLN CCLPSSL
//