ID F8WBR3_HUMAN Unreviewed; 564 AA. AC F8WBR3; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 16-JAN-2019, entry version 57. DE SubName: Full=Roundabout homolog 2 {ECO:0000313|Ensembl:ENSP00000418117}; GN Name=ROBO2 {ECO:0000313|Ensembl:ENSP00000418117}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000418117, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000418117, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., RA Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., RA Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., RA Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000418117} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC016942; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC024256; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC026877; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC067717; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC117514; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC126467; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC130004; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC131154; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC876890; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F8WBR3; -. DR EPD; F8WBR3; -. DR jPOST; F8WBR3; -. DR MaxQB; F8WBR3; -. DR PeptideAtlas; F8WBR3; -. DR PRIDE; F8WBR3; -. DR Ensembl; ENST00000473767; ENSP00000418117; ENSG00000185008. DR UCSC; uc062lpq.1; human. DR EuPathDB; HostDB:ENSG00000185008.17; -. DR HGNC; HGNC:10250; ROBO2. DR OpenTargets; ENSG00000185008; -. DR eggNOG; KOG4222; Eukaryota. DR eggNOG; ENOG410XPQS; LUCA. DR GeneTree; ENSGT00940000156324; -. DR ChiTaRS; ROBO2; human. DR Proteomes; UP000005640; Chromosome 3. DR Bgee; ENSG00000185008; Expressed in 148 organ(s), highest expression level in forebrain. DR ExpressionAtlas; F8WBR3; baseline and differential. DR GO; GO:0030673; C:axolemma; IEA:InterPro. DR GO; GO:0007411; P:axon guidance; IEA:InterPro. DR GO; GO:0007155; P:cell adhesion; IEA:InterPro. DR GO; GO:0001822; P:kidney development; IEA:InterPro. DR GO; GO:0035385; P:Roundabout signaling pathway; IEA:InterPro. DR CDD; cd00063; FN3; 1. DR Gene3D; 2.60.40.10; -; 6. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR013106; Ig_V-set. DR InterPro; IPR009138; Neural_cell_adh. DR InterPro; IPR032985; Robo2. DR PANTHER; PTHR44096:SF2; PTHR44096:SF2; 1. DR Pfam; PF07679; I-set; 2. DR PRINTS; PR01838; NCAMFAMILY. DR SMART; SM00409; IG; 5. DR SMART; SM00408; IGc2; 5. DR SMART; SM00406; IGv; 3. DR SUPFAM; SSF48726; SSF48726; 5. DR SUPFAM; SSF49265; SSF49265; 1. DR PROSITE; PS50853; FN3; 1. DR PROSITE; PS50835; IG_LIKE; 5. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:F8WBR3, KW ECO:0000213|PeptideAtlas:F8WBR3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00923712}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 564 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003385475. FT DOMAIN 31 127 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 133 220 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 225 309 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 314 409 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 417 504 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 524 564 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. SQ SEQUENCE 564 AA; 62524 MW; 4620C64FC7227B91 CRC64; MSLLMFTQLL LCGFLYVRVD GSRLRQEDFP PRIVEHPSDV IVSKGEPTTL NCKAEGRPTP TIEWYKDGER VETDKDDPRS HRMLLPSGSL FFLRIVHGRR SKPDEGSYVC VARNYLGEAV SRNASLEVAL LRDDFRQNPT DVVVAAGEPA ILECQPPRGH PEPTIYWKKD KVRIDDKEER ISIRGGKLMI SNTRKSDAGM YTCVGTNMVG ERDSDPAELT VFERPTFLRR PINQVVLEEE AVEFRCQVQG DPQPTVRWKK DDADLPRGRY DIKDDYTLRI KKTMSTDEGT YMCIAENRVG KMEASATLTV RAPPQFVVRP RDQIVAQGRT VTFPCETKGN PQPAVFWQKE GSQNLLFPNQ PQQPNSRCSV SPTGDLTITN IQRSDAGYYI CQALTVAGSI LAKAQLEVTD VLTDRPPPII LQGPANQTLA VDGTALLKCK ATGDPLPVIS WLKEGFTFPG RDPRATIQEQ GTLQIKNLRI SDTGTYTCVA TSSSGETSWS AVLDVTESGA TISKNYDLSD LPGPPSKPQV TDVTKNSVTL SWQPGTPGTL PASAYIIEAF RYVV //