ID   F8WAQ1_HUMAN            Unreviewed;       722 AA.
AC   F8WAQ1;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   16-JAN-2019, entry version 65.
DE   SubName: Full=Sushi domain-containing protein 1 {ECO:0000313|Ensembl:ENSP00000363381};
GN   Name=SUSD1 {ECO:0000313|Ensembl:ENSP00000363381};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000363381, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000363381, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000363381}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR   EMBL; AL138756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL158824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001269572.1; NM_001282643.1.
DR   UniGene; Hs.494827; -.
DR   ProteinModelPortal; F8WAQ1; -.
DR   jPOST; F8WAQ1; -.
DR   PeptideAtlas; F8WAQ1; -.
DR   PRIDE; F8WAQ1; -.
DR   Ensembl; ENST00000374263; ENSP00000363381; ENSG00000106868.
DR   GeneID; 64420; -.
DR   UCSC; uc010muj.5; human.
DR   CTD; 64420; -.
DR   EuPathDB; HostDB:ENSG00000106868.16; -.
DR   HGNC; HGNC:25413; SUSD1.
DR   OpenTargets; ENSG00000106868; -.
DR   eggNOG; ENOG410IR6W; Eukaryota.
DR   eggNOG; ENOG4111HTA; LUCA.
DR   GeneTree; ENSGT00390000013892; -.
DR   OrthoDB; 1174178at2759; -.
DR   ChiTaRS; SUSD1; human.
DR   GenomeRNAi; 64420; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000106868; Expressed in 163 organ(s), highest expression level in kidney.
DR   ExpressionAtlas; F8WAQ1; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00033; CCP; 2.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   Pfam; PF07645; EGF_CA; 2.
DR   Pfam; PF00084; Sushi; 2.
DR   SMART; SM00032; CCP; 2.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00179; EGF_CA; 2.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   SUPFAM; SSF57535; SSF57535; 2.
DR   PROSITE; PS00010; ASX_HYDROXYL; 2.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 3.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS50923; SUSHI; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00032677};
KW   Proteomics identification {ECO:0000213|MaxQB:F8WAQ1,
KW   ECO:0000213|PeptideAtlas:F8WAQ1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00594563};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30    722       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003385534.
FT   DOMAIN       35     72       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN       73    112       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      125    162       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      177    236       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      237    296       Sushi. {ECO:0000259|PROSITE:PS50923}.
SQ   SEQUENCE   722 AA;  80476 MW;  445FD714E49FE623 CRC64;
     MGRGPWDAGP SRRLLPLLLL LGLARGAAGA PGPDGLDVCA TCHEHATCQQ REGKKICICN
     YGFVGNGRTQ CVDKNECQFG ATLVCGNHTS CHNTPGGFYC ICLEGYRATN NNKTFIPNDG
     TFCTDIDECE VSGLCRHGGR CVNTHGSFEC YCMDGYLPRN GPEPFHPTTD ATSCTEIDCG
     TPPEVPDGYI IGNYTSSLGS QVRYACREGF FSVPEDTVSS CTGLGTWESP KLHCQEINCG
     NPPEMRHAIL VGNHSSRLGG VARYVCQEGF ESPGGKITSV CTEKGTWRES TLTCTEILTK
     INDVSLFNDT CVRWQINSRR INPKISYVIS IKGQRLDPME SVREETVNLT TDSRTPEVCL
     ALYPGTNYTV NISTAPPRRS MPAVIGFQTA EVDLLEDDGS FNISIFNETC LKLNRRSRKV
     GSEHMYQFTV LGQRWYLANF SHATSFNFTT REQVPVVCLD LYPTTDYTVN VTLLRSPKRH
     SVQITIATPP AVKQTISNIS GFNETCLRWR SIKTADMEEM YLFHIWGQRW YQKEFAQEMT
     FNISSSSRDP EVCLDLRPGT NYNVSLRALS SELPVVISLT TQITEPPLPE VEFFTVHRGP
     LPRLRLRKAK EKNGPISSYQ VLVLPLALQS TFSCDSEGAS SFFSNASDAD GYVAAELLAK
     DVPDDAMEIP IGDRLYYGEY YNAPLKRGSD YCIILRITSE WNKIRHSCCC RWRVLDWVPW
     LL
//