ID   F8W9H0_HUMAN            Unreviewed;       149 AA.
AC   F8W9H0;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   16-JAN-2019, entry version 40.
DE   SubName: Full=Vitamin K epoxide reductase complex subunit 1 {ECO:0000313|Ensembl:ENSP00000300851};
GN   Name=VKORC1 {ECO:0000313|Ensembl:ENSP00000300851};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000300851, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000300851, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000300851}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC135050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F8W9H0; -.
DR   jPOST; F8W9H0; -.
DR   MaxQB; F8W9H0; -.
DR   PeptideAtlas; F8W9H0; -.
DR   PRIDE; F8W9H0; -.
DR   Ensembl; ENST00000300851; ENSP00000300851; ENSG00000167397.
DR   UCSC; uc059tks.1; human.
DR   EuPathDB; HostDB:ENSG00000167397.14; -.
DR   HGNC; HGNC:23663; VKORC1.
DR   OpenTargets; ENSG00000167397; -.
DR   eggNOG; ENOG410J0HT; Eukaryota.
DR   eggNOG; ENOG4111UX7; LUCA.
DR   GeneTree; ENSGT00940000157421; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000167397; Expressed in 226 organ(s), highest expression level in liver.
DR   ExpressionAtlas; F8W9H0; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
DR   InterPro; IPR012932; VKOR.
DR   Pfam; PF07884; VKOR; 1.
DR   SMART; SM00756; VKc; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    149       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003379424.
FT   DOMAIN        5    120       VKc. {ECO:0000259|SMART:SM00756}.
SQ   SEQUENCE   149 AA;  15952 MW;  600482CB3282B7C2 CRC64;
     MGSTWGSPGW VRLALCLTGL VLSLYALHVK AARARDRDYR ALCDVGTAIS CSRVFSSRVQ
     GTGLTVLTWF HPTPPLCQVG QGFRAGGACA GTGQHPQSIQ QHIRLHLLHT TAIVRLPADT
     LGLCPDAAEL PGVSRWFCLP GLDPVLRAL
//