ID F8W9C3_HUMAN Unreviewed; 3388 AA. AC F8W9C3; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 16-JAN-2019, entry version 61. DE SubName: Full=CUB and sushi domain-containing protein 1 {ECO:0000313|Ensembl:ENSP00000383047}; GN Name=CSMD1 {ECO:0000313|Ensembl:ENSP00000383047}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000383047, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000383047, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16421571; DOI=10.1038/nature04406; RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., RA Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., RA Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., RA Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T., RA Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., RA DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G., RA Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., RA Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., RA O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K., RA Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., RA Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., RA Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., RA Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., RA Lander E.S.; RT "DNA sequence and analysis of human chromosome 8."; RL Nature 439:331-335(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000383047} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSP00000473617} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2013) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC021523; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC023296; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC026991; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC087692; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC135324; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458665; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458666; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458667; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR jPOST; F8W9C3; -. DR PRIDE; F8W9C3; -. DR Ensembl; ENST00000400186; ENSP00000383047; ENSG00000183117. DR Ensembl; ENST00000602723; ENSP00000473617; ENSG00000183117. DR UCSC; uc064jzm.1; human. DR EuPathDB; HostDB:ENSG00000183117.18; -. DR HGNC; HGNC:14026; CSMD1. DR OpenTargets; ENSG00000183117; -. DR GeneTree; ENSGT00940000155701; -. DR ChiTaRS; CSMD1; human. DR Proteomes; UP000005640; Chromosome 8. DR Bgee; ENSG00000183117; Expressed in 135 organ(s), highest expression level in primary visual cortex. DR ExpressionAtlas; F8W9C3; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR CDD; cd00033; CCP; 25. DR CDD; cd00041; CUB; 14. DR Gene3D; 2.60.120.290; -; 14. DR InterPro; IPR000859; CUB_dom. DR InterPro; IPR035914; Sperma_CUB_dom_sf. DR InterPro; IPR035976; Sushi/SCR/CCP_sf. DR InterPro; IPR000436; Sushi_SCR_CCP_dom. DR Pfam; PF00431; CUB; 14. DR Pfam; PF00084; Sushi; 25. DR SMART; SM00032; CCP; 25. DR SMART; SM00042; CUB; 14. DR SUPFAM; SSF49854; SSF49854; 14. DR SUPFAM; SSF57535; SSF57535; 25. DR PROSITE; PS01180; CUB; 14. DR PROSITE; PS50923; SUSHI; 25. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00059, KW ECO:0000256|SAAS:SAAS00887447}; Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|EPD:F8W9C3, KW ECO:0000213|PeptideAtlas:F8W9C3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 3388 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014571690. FT TRANSMEM 3312 3333 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 32 140 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 143 204 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 208 312 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 347 409 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 412 523 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 526 583 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 585 693 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 696 757 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 759 867 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 872 929 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 931 1041 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 1044 1103 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1105 1213 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 1216 1276 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1278 1387 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 1390 1450 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1452 1560 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 1563 1624 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1626 1734 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 1740 1801 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1803 1911 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 1914 1973 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 1975 2083 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 2086 2145 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2147 2258 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 2257 2318 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2320 2431 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 2431 2493 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2494 2555 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2556 2620 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2621 2678 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2679 2736 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2737 2799 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2800 2857 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2861 2918 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2919 2976 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 2977 3034 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 3038 3096 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 3097 3156 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DISULFID 554 581 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 900 927 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 1278 1305 {ECO:0000256|PROSITE-ProRule:PRU00059}. FT DISULFID 2649 2676 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2707 2734 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2770 2797 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2828 2855 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2889 2916 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2947 2974 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 3005 3032 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 3067 3094 {ECO:0000256|PROSITE-ProRule:PRU00302}. SQ SEQUENCE 3388 AA; 370271 MW; 5CBFB8F99FB626B9 CRC64; MTAWRRFQSL LLLLGLLVLC ARLLTAAKGQ NCGGLVQGPN GTIESPGFPH GYPNYANCTW IIITGERNRI QLSFHTFALE EDFDILSVYD GQPQQGNLKV RLSGFQLPSS IVSTGSILTL WFTTDFAVSA QGFKALYEVL PSHTCGNPGE ILKGVLHGTR FNIGDKIRYS CLPGYILEGH AILTCIVSPG NGASWDFPAP FCRAEGACGG TLRGTSSSIS SPHFPSEYEN NADCTWTILA EPGDTIALVF TDFQLEEGYD FLEISGTEAP SIWLTGMNLP SPVISSKNWL RLHFTSDSNH RRKGFNAQFQ VKKAIELKSR GVKMLPSKDG SHKNSVLSQG GVALVSDMCP DPGIPENGRR AGSDFSRVGA NVQFSCEDNY VLQGSKSITC QRVTETLAAW SDHRPICRAR TCGSNLRGPS GVITSPNYPV QYEDNAHCVW VITTTDPDKV IKLAFEEFEL ERGYDTLTVG DAGKVGDTRS VLYVLTGSSV PDLIVSMSNQ MWLHLQSDDS IGSPGFKAVY QEIEKGGCGD PGIPAYGKRT GSSFLHGDTL TFECPAAFEL VGERVITCQQ NNQWSGNKPS CVFSCFFNFT ASSGIILSPN YPEEYGNNMN CVWLIISEPG SRIHLIFNDF DVEPQFDFLA VKDDGISDIT VLGTFSGNEV PSQLASSGHI VRLEFQSDHS TTGRGFNITY TTFGQNECHD PGIPINGRRF GDRFLLGSSV SFHCDDGFVK TQGSESITCI LQDGNVVWSS TVPRCEAPCG GHLTASSGVI LPPGWPGYYK DSLHCEWIIE AKPGHSIKIT FDRFQTEVNY DTLEVRDGPA SSSPLIGEYH GTQAPQFLIS TGNFMYLLFT TDNSRSSIGF LIHYESVTLE SDSCLDPGIP VNGHRHGGDF GIRSTVTFSC DPGYTLSDDE PLVCERNHQW NHALPSCDAL CGGYIQGKSG TVLSPGFPDF YPNSLNCTWT IEVSHGKGVQ MIFHTFHLES SHDYLLITED GSFSEPVARL TGSVLPHTIK AGLFGNFTAQ LRFISDFSIS YEGFNITFSE YDLEPCDDPG VPAFSRRIGF HFGVGDSLTF SCFLGYRLEG ATKLTCLGGG RRVWSAPLPR CVAECGASVK GNEGTLLSPN FPSNYDNNHE CIYKIETEAG KGIHLRTRSF QLFEGDTLKV YDGKDSSSRP LGTFTKNELL GLILNSTSNH LWLEFNTNGS DTDQGFQLTY TSFDLVKCED PGIPNYGYRI RDEGHFTDTV VLYSCNPGYA MHGSNTLTCL SGDRRVWDKP LPSCIAECGG QIHAATSGRI LSPGYPAPYD NNLHCTWIIE ADPGKTISLH FIVFDTEMAH DILKVWDGPV DSDILLKEWS GSALPEDIHS TFNSLTLQFD SDFFISKSGF SIQFSTSIAA TCNDPGMPQN GTRYGDSREA GDTVTFQCDP GYQLQGQAKI TCVQLNNRFF WQPDPPTCIA ACGGNLTGPA GVILSPNYPQ PYPPGKECDW RVKVNPDFVI ALIFKSFNME PSYDFLHIYE GEDSNSPLIG SYQGSQAPER IESSGNSLFL AFRSDASVGL SGFAIEFKEK PREACFDPGN IMNGTRVGTD FKLGSTITYQ CDSGYKILDP SSITCVIGAD GKPSWDQVLP SCNAPCGGQY TGSEGVVLSP NYPHNYTAGQ ICLYSITVPK EFVVFGQFAY FQTALNDLAE LFDGTHAQAR LLSSLSGSHS GETLPLATSN QILLRFSAKS GASARGFHFV YQAVPRTSDT QCSSVPEPRY GRRIGSEFSA GSIVRFECNP GYLLQGSTAL HCQSVPNALA QWNDTIPSCV VPCSGNFTQR RGTILSPGYP EPYGNNLNCI WKIIVTEGSG IQIQVISFAT EQNWDSLEIH DGGDVTAPRL GSFSGTTVPA LLNSTSNQLY LHFQSDISVA AAGFHLEYKT VGLAACQEPA LPSNSIKIGD RYMVNDVLSF QCEPGYTLQG RSHISCMPGT VRRWNYPSPL CIATCGGTLS TLGGVILSPG FPGSYPNNLD CTWRISLPIG YGAHIQFLNF STEANHDFLE IQNGPYHTSP MIGQFSGTDL PAALLSTTHE TLIHFYSDHS QNRQGFKLAY QAYELQNCPD PPPFQNGYMI NSDYSVGQSV SFECYPGYIL IGHPVLTCQH GINRNWNYPF PRCDAPCGYN VTSQNGTIYS PGFPDEYPIL KDCIWLITVP PGHGVYINFT LLQTEAVNDY IAVWDGPDQN SPQLGVFSGN TALETAYSST NQVLLKFHSD FSNGGFFVLN FHAFQLKKCQ PPPAVPQAEM LTEDDDFEIG DFVKYQCHPG YTLVGTDILT CKLSSQLQFE GSLPTCEAQC PANEVRTGSS GVILSPGYPG NYFNSQTCSW SIKVEPNYNI TIFVDTFQSE KQFDALEVFD GSSGQSPLLV VLSGNHTEQS NFTSRSNQLY LRWSTDHATS KKGFKIRYAA PYCSLTHPLK NGGILNRTAG AVGSKVHYFC KPGYRMVGHS NATCRRNPLG MYQWDSLTPL CQAVSCGIPE SPGNGSFTGN EFTLDSKVVY ECHEGFKLES SQQATAVCQE DGLWSNKGKP PTCKPVACPS IEAQLSEHVI WRLVSGSLNE YGAQVLLSCS PGYYLEGWRL LRCQANGTWN IGDERPSCRA GHCGSPDPIV NGHISGDGFS YRDTVVYQCN PGFRLVGTSV RICLQDHKWS GQTPVCVPIT CGHPGNPAHG FTNGSEFNLN DVVNFTCNTG YLLQGVSRAQ CRSNGQWSSP LPTCRVVNCS DPGFVENAIR HGQQNFPESF EYGMSILYHC KKGFYLLGSS ALTCMANGLW DRSLPKCLAI SCGHPGVPAN AVLTGELFTY GAVVHYSCRG SESLIGNDTR VCQEDSHWSG ALPHCTGNNP GFCGDPGTPA HGSRLGDDFK TKSLLRFSCE MGHQLRGSPE RTCLLNGSWS GLQPVCEAVL CPQPPPVQNG TVEGSDFRWG SSISYSCMDG YQLSHSAILS CEGRGVWKGE IPQCLPVFCG DPGIPAEGRL SGKSFTYKSE VFFQCKSPFI LVGSSRRVCQ ADGTWSGIQP TCIDPAHNTC PDPGTPHFGI QNSSRGYEVG STVFFRCRKG YHIQGSTTRT CLANLTWSGI QTECIPHACR QPETPAHADV RAIDLPTFGY TLVYTCHPGF FLAGGSEHRT CKADMKWTGK SPVCKSKGVR EVNETVTKTP VPSDVFFVNS LWKGYYEYLG KRQPATLTVD WFNATSSKVN ATFSEASPVE LKLTGIYKKE EAHLLLKAFQ IKGQADIFVS KFENDNWGLD GYVSSGLERG GFTFQGDIHG KDFGKFKLER QDPLNPDQDS SSHYHGTSSG SVAAAILVPF FALILSGFAF YLYKHRTRPK VQYNGYAGHE NSNGQASFEN PMYDTNLKPT EAKAVRFDTT LNTVCTVV //