ID   F8W816_HUMAN            Unreviewed;       443 AA.
AC   F8W816;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   16-JAN-2019, entry version 48.
DE   SubName: Full=Cytochrome P450 2A7 {ECO:0000313|Ensembl:ENSP00000291764};
GN   Name=CYP2A7 {ECO:0000313|Ensembl:ENSP00000291764};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000291764, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000291764, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000291764}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC       {ECO:0000256|RuleBase:RU000461}.
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DR   EMBL; AC008537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_085079.2; NM_030589.2.
DR   UniGene; Hs.719890; -.
DR   ProteinModelPortal; F8W816; -.
DR   PeptideAtlas; F8W816; -.
DR   PRIDE; F8W816; -.
DR   DNASU; 1549; -.
DR   Ensembl; ENST00000291764; ENSP00000291764; ENSG00000198077.
DR   GeneID; 1549; -.
DR   UCSC; uc002opn.3; human.
DR   CTD; 1549; -.
DR   EuPathDB; HostDB:ENSG00000198077.10; -.
DR   HGNC; HGNC:2611; CYP2A7.
DR   OpenTargets; ENSG00000198077; -.
DR   GeneTree; ENSGT00940000154117; -.
DR   OrthoDB; 702827at2759; -.
DR   ChiTaRS; CYP2A7; human.
DR   GenomeRNAi; 1549; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000198077; Expressed in 76 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; F8W816; baseline and differential.
DR   Genevisible; F8W816; HS.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Heme {ECO:0000256|RuleBase:RU000461};
KW   Iron {ECO:0000256|RuleBase:RU000461};
KW   Metal-binding {ECO:0000256|RuleBase:RU000461};
KW   Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:F8W816};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    443       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003385517.
SQ   SEQUENCE   443 AA;  50667 MW;  31F5A7E6D53EE877 CRC64;
     MLASGLLLVA LLACLTVMVL MSVWQQRKSR GKLPPGPTPL PFIGNYLQLN TEHICDSIMK
     VSQGVAFSNG ERAKQLLRFA IATLRDFGVG KRGIEERIQE ESGFLIEAIR STHGANIDPT
     FFLSRTVSNV ISSIVFGDRF DYEDKEFLSL LSMMLGIFQF TSTSTGQLYE MFSSVMKHLP
     GPQQQAFKLL QGLEDFIAKK VEHNQRTLDP NSPQDFIDSF LIHMQEEEKN PNTEFYLKNL
     MMSTLNLFIA GTETVSTTLR YGFLLLMKHP EVEAKVHEEI DRVIGKNRQP KFEDRTKMPY
     MEAVIHEIQR FGDVIPMSLA RRVKKDTKFR DFFLPKGTEV FPMLGSVLRD PSFFSNPQDF
     NPQHFLDDKG QFKKSDAFVP FSIGKRNCFG EGLARMELFL FFTTVMQNFR LKSSQSPKDI
     DVSPKHVVFA TIPRNYTMSF LPR
//